Cytogenetic analysis has traditionally focused on the clonal chromosome aberrations, or
CCAs, and considered the large number of diverse non-clonal chromosome aberrations, or …

Current cytogenetics has largely focused its efforts on the identification of recurrent
karyotypic alterations, also known as clonal chromosomal aberrations (CCAs). The rationale …

A key feature of cancer chromosomes and genomes is their high level of dynamics and the
ability to constantly evolve. This unique characteristic forms the basis of genetic …

Chromosomal aberrations during cell division represent one of the first recognized features
of human cancer cells, and modern detection methods have revealed the pervasiveness of …

Cancer cells are typically characterized by complex karyotypes including both structural and
numerical changes, with aneuploidy being a ubiquitous feature. It is becoming increasingly …

Human cancers harbor great numbers of genomic alterations. One of the most common
alterations is aneuploidy, an imbalance at the chromosome level. Some aneuploid cancer …

The establishment of the correct conceptual framework is vital to any scientific discipline
including cancer research. Influenced by hematologic cancer studies, the current cancer …

Recently, non-clonal chromosomal alterations previously unappreciated are being proposed
to be included in cytogenetic practice. The aim of this inclusion is to obtain a greater …

Valind et al. report a significant finding, that constitutional aneuploidy itself does not lead to
cancer-like chromosomal instability (CIN)(1). This observation, however, may not fully …

Background Cancer is a complex disease that is the second leading cause of death in the
United States. Despite research efforts, the ability to manage cancer and select optimal …