Simple Summary Breast cancer is a heterogeneous disease that is driven by genetic,
epigenetic and phenotypic modifications and is also affected by the microenvironment and …

Breast cancer is a heterogeneous disease. There is a high degree of diversity between and
within tumors as well as among cancer-bearing individuals, and all of these factors together …

Breast cancer is a heterogeneous disease and differs greatly among different patients
(intertumor heterogeneity) and even within each individual tumor (intratumor heterogeneity) …

Introduction Breast cancer is the most common cancer and the second leading cause of
cancer-related death in women worldwide. Despite the early detection of breast cancer and …

Tumor heterogeneity impinges on prognosis, response to therapy, and metastasis. As such,
heterogeneity is one of the most important and clinically relevant areas of cancer research …

Breast cancer comprises a heterogeneous group of tumor subtypes, whether defined by
immunohistochemistry of key proteins, RNA expression profiles, or genetic alterations, and …

Cancer progression is a dynamic process of clonal adaptation to changing
microenvironments. From the single founder cell until the clinical detection of tumours, there …

Traditionally, intertumour heterogeneity in breast cancer has been documented in terms of
different histological subtypes, treatment sensitivity profiles, and clinical outcomes among …

The identification of extensive genetic heterogeneity in human breast carcinomas poses a
significant challenge for designing effective treatment regimens. Significant genomic …

More women die from breast cancer across the world today than from any other type of
malignancy. The clinical course of breast cancer varies tremendously between patients …