Breast cancer is a genetic disease. Like other human cancers, it is thought to occur as the
result of progressive accumulation of genetic aberrations. These aberrations result in a …

Breast cancer is the most common cancer type among women worldwide. With breast
cancer patients and survivors being reported to experience a repertoire of symptoms that are …

Simple Summary Internationally, in women, breast cancer (BC) is the most common cancer
type and is the leading cause of cancer-related death. There are two main histological …

Cancer arises as a consequence of mutations in genomes of cancer cells, which over time
allow them to proliferate and spread to distant sites. Large-scale sequencing of cancer …

Breast cancer has for long been recognized as a highly diverse tumor group, but the
underlying genetic basis has been elusive. Here, we report an extensive molecular …

Breast cancers are comprised of molecularly distinct subtypes that may respond differently to
pathway-targeted therapies now under development. Collections of breast cancer cell lines …

Individual cancer cells carry a bewildering number of distinct genomic alterations (eg, copy
number variations and mutations), making it a challenge to uncover genomic-driven …

Breast cancer (BC) displays striking clinical, morphological, and behavioural diversity within
a single tumour and between tumours. Currently, mounting evidence indicates that the …

Abstract Learning Objectives After completing this course, the reader will be able to: Assess
emerging data on the use of genetic groupings of breast cancer as predictive factors, and …

Our understanding of breast cancer as a clinical and biologic entity has been gaining
granularity for several decades; in particular, the importance of hormone receptors and …