CD4 is known to be an important receptor for human immunodeficiency virus type 1 (HIV-1)
infection of T lymphocytes and macrophages. However, the limiting steps in CD4-dependent …

There is increasing evidence that CD8 lymphocytes may represent targets for infection by
human immunodeficiency virus type 1 (HIV-1) in vivo whose destruction may contribute to …

To characterize the role of CD4 in human immunodeficiency virus type 1 (HIV-1) infection of
macrophages, we examined the expression of CD4 by primary human monocyte-derived …

Background: HIV-2 is less pathogenic than HIV-1. In contrast to HIV-1, many isolates of HIV-
2, including primary isolates, can infect cells independently of CD4. Objective: To compare …

Human immunodeficiency virus type 1 (HIV-1) selectively infects cells expressing the CD4
molecule, resulting in substantial quantitative and qualitative defects in CD4+ T lymphocyte …

CD4 molecules on human cells function as a major receptor for human immunodeficiency
virus (HIV); however, certain CD4-negative cell types may also be susceptible to infection …

Replication of the human immunodeficiency virus type 1 (HIV-1) underlies the pathogenesis
and progression of the acquired immunodeficiency syndrome (AIDS). A soluble form of the …

Human immunodeficiency virus (HIV)-infected CD8 lymphocytes have been reported in vivo,
but the mechanism of infection remains unclear. Experiments using the thy/hu mouse model …

Neutralization of human immunodeficiency virus type 1 (HIV-1) infection with soluble CD4
(sCD4) can be achieved over a broad range of concentrations for different virus strains …

Strains of human immunodeficiency virus type 1 (HIV-1) that use the coreceptor CXCR4 (X4
strains) become laboratory adapted (LA) when selected for ability to replicate in leukemic T …