New frontiers in androgen biosynthesis and metabolism : Current Opinion in Endocrinology,
Diabetes and Obesity New frontiers in androgen biosynthesis and metabolism : Current …

Androgens are essential sex steroid hormones for both sexes. Testosterone (T) is the
predominant androgen in males, while in adult females, T concentrations are about 15-fold …

The pathways of androgen biosynthesis in human beings have been studied for decades,
and the major pathways and enzymes responsible for testosterone and dihydrotestosterone …

Benign prostatic hyperplasia (BPH) as well as prostate cancer (CaP) are prevalent in the
aging male population, and both the diseases display androgen-dependence when the …

Castration resistant prostate cancer (CRPC) remains androgen dependant despite castrate
levels of circulating testosterone following androgen deprivation therapy, the first line of …

OBJECTIVE Knowledge of the molecular and cellular changes that occur during the
transition of hormone‐naïve to castration‐resistant prostate cancer (CRPC) is increasing …

Regulation of androgen production is poorly understood. Adrenarche is the physiologic
event in mid-childhood when the adrenal zona reticularis starts to produce androgens …

It is well recognized that there are two androgens, namely testosterone (T) and
dihydrotestosterone (DHT); T plays an important role in the testis and muscle, and DHT is …

Androgens are precursors for sex steroids and are predominantly produced in the human
gonads and the adrenal cortex. They are important for intrauterine and postnatal sexual …

The androgen receptor (AR) is a key regulator of prostate growth and the principal drug
target for the treatment of prostate cancer. Previous studies have mapped AR targets and …