Methods: Patients with molecularly confirmed BWS seen from 2004-2023 were included to
develop this system. Relationships among BIG scores, tongue reduction surgery, BWS …

Tongue reduction surgery is often pursued to manage the adverse effects of macroglossia in
patients with Beckwith-Wiedemann syndrome (BWS). This study characterized dental …

Methods: Patients with BWS seen in consultation for macroglossia from 2009-2022 were
reviewed for phenotype, molecular diagnosis, tongue reduction status, timing of surgery …

BACKGROUND: Macroglossia is a cardinal feature of Beckwith-Wiedemann syndrome
(BWS). Optimal timing of tongue reduction is debated due to the spectrum of phenotypic …

Objective: This review was conducted to define the natural history of unoperated Beckwith-
Wiedemann syndrome (BWS) macroglossia and the effect of tongue reduction surgery upon …

Background: Macroglossia, a cardinal feature of the (epi) genetic disorder Beckwith-
Wiedemann syndrome, is associated with obstructive sleep apnea, speech and/or feeding …

Abstract Beckwith-Wiedemann Syndrome (BWS) is a rare genetic disorder that causes
developmental defects as well as an elevated risk of malignancies. Macroglossia, or an …

Methods: Blood mosaicism levels and BWS clinical score were recorded in patients with
macroglossia referred to plastic surgery for evaluation. Associations among blood …

Introduction Macroglossia occurs in 80% to 99% of patients with Beckwith-Wiedemann
syndrome (BWS) and a variety of surgical techniques for tongue reduction are offered by …

PURPOSE: Most patients with Beckwith-Wiedemann syndrome (BWS) have macroglossia
with some cases requiring tongue reduction surgery (TRS). This study leverages our …