Potential of an aligned porous hydrogel scaffold combined with periodontal ligament stem cells or gingival mesenchymal stem cells to promote tissue regeneration in …

W Wang, A Wang, G Hu, M Bian, L Chen… - ACS Biomaterials …, 2023 - ACS Publications
Periodontal tissue regeneration is a major challenge in tissue engineering due to its
regenerated environment complexity. It aims to regenerate not only the supporting alveolar …

Matrix control of periodontal ligament cell activity via synthetic hydrogel scaffolds

D Fraser, T Nguyen, DSW Benoit - Tissue Engineering Part A, 2021 - liebertpub.com
Rebuilding the tooth-supporting tissues (periodontium) destroyed by periodontitis remains a
clinical challenge. Periodontal ligament cells (PDLCs), multipotent cells within the …

In vitro evaluation of poly (vinyl alcohol)/collagen blended hydrogels for regulating human periodontal ligament fibroblasts and gingival fibroblasts

T Zhou, K Zheng, B Sui, AR Boccaccini, J Sun - International Journal of …, 2020 - Elsevier
Periodontitis is a chronic inflammatory disease that can destroy periodontal tissue. Guided
tissue regeneration (GTR) is widely applied to treat periodontitis. However, the challenge is …

Periodontal ligament-mimetic fibrous scaffolds regulate YAP-associated fibroblast behaviors and promote regeneration of periodontal defect in relation to the scaffold …

JI Kim, JY Kim, G Bhattarai, HS So… - … Applied Materials & …, 2022 - ACS Publications
Although multiple regenerative strategies are being developed for periodontal
reconstruction, guided periodontal ligament (PDL) regeneration is difficult because of its …

Chitosan-based trilayer scaffold for multitissue periodontal regeneration

EM Varoni, S Vijayakumar, E Canciani… - Journal of Dental …, 2018 - journals.sagepub.com
Periodontal regeneration is still a challenge for periodontists and tissue engineers, as it
requires the simultaneous restoration of different tissues—namely, cementum, gingiva …

Bioprinting-based PDLSC-ECM screening for in vivo repair of alveolar bone defect using cell-laden, injectable and photocrosslinkable hydrogels

Y Ma, Y Ji, T Zhong, W Wan, Q Yang, A Li… - ACS Biomaterials …, 2017 - ACS Publications
Periodontitis is an inflammatory disease worldwide that may result in periodontal defect
(especially alveolar bone defect) and even tooth loss. Stem-cell-based approach combined …

Investigating the repair of alveolar bone defects by gelatin methacrylate hydrogels-encapsulated human periodontal ligament stem cells

J Pan, J Deng, L Yu, Y Wang, W Zhang, X Han… - Journal of Materials …, 2020 - Springer
Although various efforts have been made to develop effective treatments for alveolar bone
defect, alveolar regeneration has been emerging as the one with the most potential Herein …

Tissue‐specific composite cell aggregates drive periodontium tissue regeneration by reconstructing a regenerative microenvironment

B Zhu, W Liu, H Zhang, X Zhao, Y Duan… - Journal of Tissue …, 2017 - Wiley Online Library
Periodontitis is the most common cause of periodontium destruction. Regeneration of
damaged tissue is the expected treatment goal. However, the regeneration of a functional …

Decellularized human periodontal ligament for periodontium regeneration

H Son, M Jeon, HJ Choi, HS Lee, IH Kim, CM Kang… - PLoS …, 2019 - journals.plos.org
Regenerating the periodontal ligament (PDL) is a crucial factor for periodontal tissue
regeneration in the presence of traumatized and periodontally damaged teeth. Various …

A chitosan‐hyaluronic acid hydrogel scaffold for periodontal tissue engineering

DG Miranda, SM Malmonge… - … Research Part B …, 2016 - Wiley Online Library
The current challenge in treating periodontitis is regenerating the periodontium. This
motivates tissue‐engineering researchers to develop scaffolds as artificial matrices that give …