HTLV-1-infection is associated with a variety of human diseases including adult T-cell
leukemia (ATL) and non-neoplastic inflammatory diseases. The latter includes HTLV-1 …

Human T cell leukemia virus type 1 (HTLV-1) was the first retrovirus to be identified as a
causative agent of a cancer in humans. In addition to cancer, adult T-cell leukemia (ATL) …

Human T-cell leukemia/lymphoma virus type 1 (HTLV-1) infects 15-20 millions individuals
worldwide. This oncoretrovirus can be transmitted through 3 ways: horizontally, vertically …

CD4+ T cells are critical for inducing and maintaining efficient humoral and cellular immune
responses to pathogens. The CD4+ T-cell response in human T-lymphotropic virus 1 (HTLV …

Human T-lymphotropic virus type 1 (HTLV-1) persists by driving clonal proliferation of
infected T lymphocytes. A high proviral load predisposes to HTLV-1–associated diseases …

Human T-cell leukemia virus type 1 (HTLV-1) integrates its proviruses into random sites in
host chromosomal DNA. Random integration of the proviruses was observed in …

Human T-cell leukemia virus type 1 (HTLV-1) is a complex retrovirus that may have been
transmitted to humans from monkeys more than ten thousands years ago. 1 The human host …

Highlights•Molecular mechanisms of HTLV-1 oncogenesis.•Innate and acquired immune
response to HTLV-1.•Clonality of HTLV-1 in vivo.•We bring together the host and viral factors …

Human T cell leukemia virus type 1 (HTLV-1) is an oncogenic human retrovirus that has
infected 10–15 million people worldwide. After a long latency, 3–5% of infected individuals …

It is 30 years since human T-cell leukemia virus type 1 (HTLV-1) was identified as the first
human retrovirus. To assess the implications of the virus for human health it is very important …