The normal functional state of the vasculature and the events leading to the development of
significant arterial disease involve the interaction of important vasoactive substances, which …

Endothelins (ET) are 21-aminoacid peptides produced in many different tissues. They were
discovered as a product of vascular endothelial cells (69), but have since been shown to be …

Endothelins are ubiquitously produced 21-amino-acid peptides that were discovered as an
endothelial product and may play important roles in cardiovascular physiology and …

Endothelins are a family of peptides, which comprises endothelin-1 (ET-1), endothelin-2 (ET-
2) and endothelin-3 (ET-3), each containing 21 amino-acids. ET-1 is a peptide secreted …

The endothelins are a family of endothelium-derived peptides that possess characteristically
sustained vasoconstrictor properties. Endothelin-1 appears to be the predominant member …

Endothelin-1 (ET-1) is a potent vasoconstrictive peptide produced by endothelial cells of
blood vessels. This peptide has quite a unique structure and pharmacological properties. ET …

Endothelins including its most abundant isoform, endothelin-1 (ET-1), are peptides acting as
vasoconstrictors when binding to ET A and ET B receptors, and, in addition to their distinct …

Summary The endothelins (ET-1, 2, and 3) constitute a family of 21 amino-acid peptides with
potent biological activities. They are synthesized in several tissues, including the vascular …

Apart from the initially described vasoconstriction, endothelins have been shown to cause a
variety of biological activities in non-vascular tissues. A rapidly growing body of data …

Endothelins are powerful vasoconstrictor peptides that also play numerous other roles. The
endothelin (ET) family consists of three peptides produced by a variety of tissues. Endothelin …