Endothelin (ET) is a potent vasoconstrictive peptide initially found in the conditioned medium
of cultured endothelial cells (1). It comprises 21 amino acid residues including four cysteine …

Endothelin, a recently discovered peptide produced by endothelial cells, contracts vascular
strips in vitro with greater potency than any previously known vasoconstrictor. Infusions of …

Peptide hormones are nearly ubiquitous in the body and play a major role in regulating
homeostasis. Serving in an endocrine, paracrine, or neuroendocrine role, peptide hormones …

Endothelin-1 is a recently discovered peptide mainly released from endothelial cells.
Hypoxia and ischemia as well as numerous factors such as angiotensin 11, thrombin and …

In spite of tremendous progress in the understanding of human disease, the search for new
mediators continues as numerous conditions remain poorly understood. In particular in …

The endothelium synthesizes and releases paracrine hormones that regulate the contraction
and physiology of vascular smooth muscle cells. 1-3 In addition to the well-described …

Endothelins are a family of potent vasoconstrictor peptides released by endothelial cells.
The production of endothelin-1 (ET-1) can be stimulated by aggregating platelets and …

The endothelins (ET) are potent 21-amino-acid vasoconstrictor peptides produced in many
different tissues, particularly in the endothelium of blood vessels. ET-1 is the main …

Abstract The endothelins, 21-amino-acid peptides produced by the endothelium of blood
vessels and many other tissues such as the kidney, brain, endocrine organs, etc., are potent …

Since its identification in 1988, 1 endothelin has attracted intensive interdisciplinary
research interest because of itsunique profile as an endo-thelium-derived vasoactive factor …