In 1985, investigators characterized a potent vasoconstrictor of endothelial origin called
endothelin (ET). Subsequently, 3 peptides were recognized that had a comparable …

Endothelins are powerful vasoconstrictor peptides that also play numerous other functions in
many different organs. Endothelin-1 (ET-1) is the most abundant and important of this family …

Endothelins (ETs) are 21-amino-acid peptides produced in many cells and tissues. The
vascular ET system is represented mainly by ET-1 produced in endothelial cells. PreproET-1 …

The sensitivity of the renal vasculature to endothelin-1 together with the effect of the peptide
on the kidney prompted investigators to study the role of endothelin-1 in renal …

The existence of a powerful endogenous endotheliumderived vasoconstrictor was predicted
from the early 1980s, but not until 1988 did Yanagisawa and colleagues first report the …

Renal homeostasis reflects a delicate balance of diverse signaling systems controlling renal
blood flow, glomerular filtration rate, and tubular reabsorp tion and secretion. Regulatory …

Objectives: We developed four selective rabbit antisera in order to compare the distribution
of immunoreactive mature endothelins and their precursors, proendothelin-1, proendothelin …

The role of endothelins (ET) in blood pressure elevation remains controversial. Data
supporting involvement of the ET system in different forms of genetic and experimental …

Endothelin has a number of actions in the kidney, and there is growing evidence that
whenever renal function is compromised, endothelin production as well as its binding to …

The endothelin family of peptides are extremely potent endogenous vasoconstrictor and
pressor agents. Of the 3 isoforms, endothelin-1 is the major isoform produced by the …