Endothelins are potent 21 amino acid vasoconstrictor isopeptides produced in different
vascular tissues, including vascular endothelium. Endothelin-1 is the main endothelin …

Endothelin, a very potent vasoconstrictor peptide consisting of 21 amino acids, was
discovered from porcine aortic endothelial cells by Yanagisawa et al.[1] in 1988. Over 2,000 …

Endothelin is an endothelial cell-derived peptide recently shown to possess potent
vasoconstrictor properties. Bolus intravenous injections of endothelin (5-450 pmol) into …

Endothelins (ETs) elicit in vivo and in vitro a potent vasoconstrictor activity after binding to
highaffinity receptors on vascular smooth muscle cells (VSMC). A617 cells, a VSM-derived …

Endothelin-1 (ET-1) is a multifunctional hormone which regulates the physiology of the
cardiovascular and renal systems. ET-1 modulates cardiac contractility, systemic and renal …

The endothelins are a family of novel 21 amino-acid peptides and are the most potent
vasoconstrictor substances yet discovered. The endothelins not only produce prolonged …

Abstract Endothelin-1 (ET-1; 0.001-1 nmol) and the ET B receptor agonist IRL-1620 (0.01-1
nmol) induced a dosedependent vasoconstriction of the arterial and venous mesenteric …

Since the discovery of the most potent vasoconstrictor peptide, endothelin, in 1988,
explosive investigations have rapidly clarified much of the basic pharmacological …

The physiologic significance of endothelin-1 (ET-1) generation in human resistance vessels
is unknown. We therefore investigated whether endothelin-converting enzyme (ECE) activity …

The endothelins (ET) are a recently discovered family of peptides which appear to be
involved in hemodynamic regulation; they have potent vasoconstrictor properties and dose …