Rho-kinase (ROCKs) is an important downstream effector of the small GTP-binding protein
Ras homolog gene family member A. There are 2 isoforms of ROCK, ROCK1 and ROCK2 …

Abstract The Rho‐associated kinases (ROCKs) can regulate cell shape and function by
modulating the actin cytoskeleton. ROCKs are serine‐threonine protein kinases that can …

Rho-associated kinases (ROCKs), the immediate downstream targets of RhoA, are
ubiquitously expressed serine-threonine protein kinases that are involved in diverse cellular …

In a variety of normal and pathological cell types, Rho-kinases I and II (ROCKI/II) play a
pivotal role in the organization of the nonmuscle and smooth muscle cytoskeleton and …

Rho-associated coiled-coil kinase (ROCK) is a major downstream effector of the small
GTPase RhoA. The ROCK family, consisting of ROCK1 and ROCK2, plays a central role in …

Rho-associated protein kinase (ROCK) is a serine-threonine kinase originally identified as a
crucial regulator of actin cytoskeleton. Recent studies have defined new functions of ROCK …

Rho kinases (ROCKs) are serine-threonine protein kinases that regulate the actin
cytoskeleton. Recent studies suggest that ROCKs also play an important role in …

Rho-kinase (ROCK) belongs to the AGC (protein kinase A/protein kinase G/protein kinase C,
PKA/PKG/PKC) family of serine/threonine kinases and is a major downstream effector of …

Introduction: Pathological cardiac fibrosis, through excessive extracellular matrix protein
deposition from fibroblasts and pro-fibrotic immune responses and vascular stiffening is …

Cancer targeted therapy, either alone or in combination with conventional chemotherapy,
could allow the survival of patients with neoplasms currently considered incurable. In recent …