Rho-associated coiled-coil forming protein kinases (ROCKs), the downstream target
proteins of RhoA, are ubiquitously expressed serine-threonine protein kinases. ROCKs have …

Hypertensive cardiac remodeling is characterized by left ventricular hypertrophy and
interstitial fibrosis, which can lead to heart failure with preserved ejection fraction. The Rho …

Twenty years ago, Rho-kinase was identified as an important downstream effector of the
small GTP-binding protein, RhoA. Thereafter, a series of studies demonstrated the important …

Background—Rho GTPase and its downstream target, Rho-associated kinase (ROCK),
have been implicated in diverse cardiovascular diseases such as cardiac hypertrophy …

The Rho kinases, or ROCKs, are a family of serine-threonine kinases that serve as key
downstream effectors for Rho GTPases. The ROCKs are increasingly recognized as critical …

The Rho-associated coiled-coil kinases (ROCK) are essential regulators of the actin
cytoskeleton; however, the structure of a full-length ROCK is unknown and the mechanisms …

RhoA and Rho-kinase (ROCK) participate in diverse cellular signaling functions such as
smooth muscle contraction, cytoskeleton rearrangement, and cell migration and …

Rho‐associated coiled‐coil kinases (ROCKs), initially identified as effectors for Rho
GTPases, play a role in cardiac cell physiology and are also expressed in the developing …

Rho kinase (ROCK) is a downstream effector of Rho family GTPases, and two highly
homologous isoforms, ROCK1 and ROCK2, are similarly inhibited by the widely used …

Although Rho-associated kinase (ROCK) activity has been implicated in cardiovascular
diseases, the tissue-and isoform-specific roles of ROCKs in the vascular response to injury …