Rho kinase (ROCK) belongs to a family of Ser/Thr protein kinases that are activated via
interaction with the small GTP-binding protein RhoA. Growing evidence suggests that RhoA …

The Rho-ROCK pathway modulates the phosphorylation level of a variety of important
signaling proteins and is thereby involved in miscellaneous cellular processes including cell …

Abstract Background Members of Rho-associated coiled-coil kinases (ROCKs) are effectors
of Rho family of small GTPases. ROCKs have multiple functions that include regulation of …

Pathological cardiac hypertrophy caused by diverse etiologies eventually leads to cardiac
dilation and functional decompensation. We have recently reported that genetic deletion of …

The small GTP-binding protein Rho plays a crucial role in a wide variety of cellular functions
through various effector proteins. Rho-kinase is a key effector protein of Rho, which is …

Rho-associated kinase (ROCK), including the ROCK-I and ROCK-II isoforms, is a protein
kinase involved in signaling from Rho to actin cytoskeleton. However, in vivo functions of …

Highlights•The structures and therapeutic importance of ROCK are outlined.•The available
inhibitors of ROCK are summarized.•The binding mechanisms of representative ROCK …

Rho-associated, coiled-coil containing kinases (ROCK) were originally identified as effectors
of the RhoA small GTPase and found to belong to the AGC family of serine/threonine …

The members of the Rho GTPase family are well known for their regulation of actin
cytoskeletal structures. In addition, they influence progression through the cell cycle. The …

Signal transduction cascades involving Rho-associated kinases (ROCK), the
serine/threonine kinases downstream effectors of Rho, have been implicated in the …