ROCKs are important regulators of the actin cytoskeleton. Because changes in the actin
cytoskeleton underlie vascular contractility and remodeling, inflammatory cell recruitment …

The Rho-associated coiled-coil containing kinases, ROCK1 and ROCK2, are important
regulators of cell shape, migration, and proliferation through effects on the actin …

ROCK, or Rho-associated coiled coil-containing protein kinase, is a member of the AGC
kinase family and has been shown to play a role in cell migration, ECM synthesis, stress …

Rho-associated coiled-coil protein kinase (ROCK) is an effector for the small GTPase Rho
and plays a pivotal role in diverse cellular activities, including cell adhesion, cytokinesis, and …

Progression of tumors to invasive and metastatic forms requires that tumor cells undergo
dramatic morphologic changes, a process regulated by Rho GTPases. Elevated expression …

In past decades, growing evidence from basic and clinical researches reveal that small
guanosine triphosphate binding protein ras homolog gene family, member A (RhoA) and its …

Identified as a major downstream effector of the small GTPase RhoA, Rho-associated coiled-
coil kinase (ROCK) is a versatile regulator of multiple cellular processes. Angiogenesis, the …

Rho-kinase (ROCKs) belongs to the family of serine/threonine kinases and is an important
downstream effector of the small GTP-binding protein RhoA. There are two isoforms of Rho …

There is growing evidence that Rho-kinases (ROCKs), the immediate downstream targets of
the small guanosine triphosphate-binding protein Rho, may contribute to cardiovascular …

Background—Macrophages play a central role in the development of atherosclerosis.
However, the signaling pathways that regulate their function are not well understood. The …