ROCKs are important regulators of the actin cytoskeleton. Because changes in the actin
cytoskeleton underlie vascular contractility and remodeling, inflammatory cell recruitment …

The Rho-associated coiled-coil containing kinases, ROCK1 and ROCK2, are important
regulators of cell shape, migration, and proliferation through effects on the actin …

Rho-associated coiled-coil protein kinase (ROCK) is an effector for the small GTPase Rho
and plays a pivotal role in diverse cellular activities, including cell adhesion, cytokinesis, and …

Progression of tumors to invasive and metastatic forms requires that tumor cells undergo
dramatic morphologic changes, a process regulated by Rho GTPases. Elevated expression …

Identified as a major downstream effector of the small GTPase RhoA, Rho-associated coiled-
coil kinase (ROCK) is a versatile regulator of multiple cellular processes. Angiogenesis, the …

In past decades, growing evidence from basic and clinical researches reveal that small
guanosine triphosphate binding protein ras homolog gene family, member A (RhoA) and its …

ROCK, or Rho-associated coiled coil-containing protein kinase, is a member of the AGC
kinase family and has been shown to play a role in cell migration, ECM synthesis, stress …

Rho-kinase (ROCKs) belongs to the family of serine/threonine kinases and is an important
downstream effector of the small GTP-binding protein RhoA. There are two isoforms of Rho …

Pulmonary fibrosis is thought to result from dysregulated wound repair after repetitive lung
injury. Many cellular responses to injury involve rearrangements of the actin cytoskeleton …

Highlights•Rho-kinase-2 is an important therapeutic target.•ROCK-2 plays a pivotal role in
the pathogenesis of vascular, neuronal disorders and cancer.•ROCK-2 selective targeting …