The Rho/ROCK pathway is involved in numerous pivotal cellular processes that have made
it an area of intense study in cancer medicine, however, Rho-associated coiled-coil …

The emerging critical implications of Rho/Rho-kinase (ROCK) signaling in
neurodegenerative diseases, glaucoma, renoprotection, diabetes and cancer have sparked …

Abnormal vascular smooth muscle cell (VSMC) contraction plays an important role in
vascular diseases. The RhoA/ROCK signaling pathway is now well recognized to mediate …

Rho kinase (ROCK) is a major downstream effector of the small GTPase RhoA. ROCK
family, consisting of ROCK1 and ROCK2, plays central roles in the organization of actin …

The Rho/rho-kinase (ROCK) pathway has an important role in the pathogenesis of several
cardiovascular diseases. The activation of ROCK is involved in the regulation of vascular …

The ROCK‐I serine/threonine protein kinase mediates the effects of RhoA to promote the
formation of actin stress fibres and integrin‐based focal adhesions. ROCK‐I phosphorylates …

RhoE belongs to the Rho GTPase family, the members of which control actin cytoskeletal
dynamics. RhoE induces stress fiber disassembly in a variety of cell types, whereas RhoA …

Abnormal proliferation and migration of vascular smooth muscle cells (VSMC) plays an
important role in vascular diseases. The Rho-associated protein kinase (ROCK) signaling …

The small GTPase Rho and its downstream effector, Rho-kinase (ROCK), regulate various
cellular functions, including organization of the actin cytoskeleton, cell adhesion and …

Effective immune responses require the precise regulation of dynamic interactions between
hematopoietic and non-hematopoietic cells. The Rho subfamily of GTPases, which includes …