In chronic hepatitis C virus (HCV) infection, exhausted HCV-specific CD8+ T cells comprise
memory-like and terminally exhausted subsets. However, little is known about the molecular …

T cell exhaustion is associated with failure to clear chronic infections and malignant cells.
Defining the molecular mechanisms of T cell exhaustion and reinvigoration is essential to …

Differentiation and fate of virus-specific CD8+ T cells after cessation of chronic antigen
stimulation is unclear. Here we show that a TCF1+ CD127+ PD1+ hepatitis C virus (HCV) …

Emerging evidence indicates that CD8+ and CD4+ T-cell immunity is differentially regulated.
Here we have delineated differences and commonalities among antiviral T-cell responses …

Spontaneous resolution of hepatitis C virus (HCV) infection in humans usually affords long-
term immunity to persistent viremia and associated liver diseases. Here, we report that …

The majority of acute hepatitis C virus (HCV) infections progress to chronicity and
progressive liver damage. Alpha interferon (IFN-α) antiviral therapy achieves the highest …

Vigorous proliferative CD4+ T cell responses are the hallmark of spontaneous clearance of
acute hepatitis C virus (HCV) infection, whereas comparable responses are absent in …

Abstract The viruses HIV-1, Epstein–Barr virus (EBV), cytomegalovirus (CMV) and hepatitis
C virus (HCV) are characterized by the establishment of lifelong infection in the human host …

BACKGROUND Chronic hepatitis C virus (HCV) infection is characterized by a severe
impairment of HCV-specific CD4+ T cell help that is driven by chronic antigen stimulation …

As acute hepatitis C virus (HCV) infection is clinically inapparent in most cases, the
immunologic correlates of recovery are not well defined. The cellular immune response is …