Hepatitis C virus (HCV) poses a global health problem because it readily establishes
persistent infection and a vaccine is not available. CD4+ CD25+ T cells have been …

Efficient maintenance of memory CD8 T cells is central to long-term protective immunity. IL-7–
and IL-15–driven homeostatic proliferation is essential for long-term memory CD8 T cell …

ABSTRACT T cell exhaustion and loss of memory potential occur during many chronic viral
infections and cancer. We investigated when during chronic viral infection virus-specific CD8 …

A hallmark of adaptive immunity is the generation of memory T cells that confer long-lived,
antigen-specific protection against repeat challenges by pathogens,,,,. Understanding the …

After viral infection, naive CD8+ T cells become activated and either differentiate into effector
cells, which eliminate virus-infected cells, or convert to memory-type T cells, awaiting re …

CD4+ T cell responses are composed of heterogeneous T cell receptor (TCR) signals that
influence the acquisition of effector and memory characteristics. We sought to define early …

Of the many dendritic cell (DC) subsets, DCs expressing the monomorphic coreceptor CD8
α-chain (CD8α) are localized permanently in lymphoid organs, whereas' tissue-derived DCs' …

Chronic hepatitis C virus (HCV) infection disrupts immune functions, including that of
cytotoxic CD8+ T-cells which are important mediators of immune response. While HCV cure …

Adaptive evolution is a key feature of T cell immunity. During acute immune responses, T
cells harboring high-affinity T cell antigen receptors (TCRs) are preferentially expanded, but …

It is thought that immunity depends on naïve CD4 T cells that proliferate in response to
microbial antigens,,,, differentiate into memory cells that produce anti-microbial …