Memory T cells can persist for extended periods in the absence of antigen, and long-term T
cell immunity is often seen after acute infections. Paradoxically, there have been …

In the setting of acute hepatitis C virus (HCV) infection, robust HCV-specific CD8+ cytotoxic T
lymphocyte (CTL) responses are associated with initial control of viremia. Despite these …

In the present study, we have investigated the anatomic distribution and the function of
different populations of HIV‐1‐and cytomegalovirus (CMV)‐specific memory CD8 T cells …

The majority of individuals who become acutely infected with hepatitis C virus (HCV)
develop chronic infection and suffer from progressive liver damage while approximately …

A continuing concern with CD28 and/or CD40 blockade-based strategies to induce
tolerance and mixed chimerism is their potential to disrupt protective immunity to preexisting …

Memory CD8 T cells are an important component of protective immunity against viral
infections, and understanding their development will aid in the design of optimal vaccines …

Clearance of primary infection often leads to the development of highly functional memory T
cells capable of rapid and long-lasting protective immunity. By contrast, chronic infections …

Chronic cytomegalovirus (CMV) infection leads to long-term maintenance of extraordinarily
large CMV-specific T cell populations. The magnitude of this so-called 'memory inflation'is …

Chronic viral infections are characterized by a state of CD8+ T-cell dysfunction that is
associated with expression of the programmed cell death 1 (PD-1) inhibitory receptor,,,. A …

CD4+ T cells are essential for immune protection against viruses, yet their multiple roles
remain ill-defined at the single-cell level in humans. Using HLA class II tetramers, we studied …