IS (Idiopathic Scoliosis) etiology: Multifactorial genetic research continues. A systematic review 1950 to 2017

A Maqsood, DK Frome, RF Gibly, JE Larson… - Journal of …, 2020 - Elsevier
Objective IS (idiopathic scoliosis) is a common spinal condition occurring in otherwise
completely healthy adolescents. The root cause of IS remains unclear. This systematic …

[HTML][HTML] Exploring the association between specific genes and the onset of idiopathic scoliosis: a systematic review

S De Salvatore, L Ruzzini, UG Longo, M Marino… - BMC Medical …, 2022 - Springer
Abstract Background Idiopathic Scoliosis (IS) is the most common spinal deformity in
adolescents, accounting for 80% of all spinal deformities. However, the etiology remains …

[HTML][HTML] The genetic epidemiology of idiopathic scoliosis

KF Gorman, C Julien, A Moreau - European Spine Journal, 2012 - Springer
Purpose Idiopathic scoliosis is a complex developmental syndrome defined by an abnormal
structural curvature of the spine. High treatment costs, chronic pain/discomfort, and the need …

[HTML][HTML] Genetics and pathogenesis of idiopathic scoliosis

A Grauers, E Einarsdottir, P Gerdhem - Scoliosis and spinal disorders, 2016 - Springer
Idiopathic scoliosis (IS), the most common spinal deformity, affects otherwise healthy
children and adolescents during growth. The aetiology is still unknown, although genetic …

Association between genetic polymorphisms and risk of adolescent idiopathic scoliosis in case-control studies: a systematic review

E Terhune, P Heyn, C Piper, C Wethey… - Journal of Medical …, 2024 - jmg.bmj.com
Background Adolescent idiopathic scoliosis (AIS) is a structural lateral spinal curvature of≥
10° with rotation. Approximately 2%–3% of children across populations are affected with …

[HTML][HTML] Genetic variants associated with the occurrence and progression of adolescent idiopathic scoliosis: a systematic review protocol

EA Terhune, PC Heyn, CR Piper, N Hadley-Miller - Systematic Reviews, 2022 - Springer
Background Adolescent idiopathic scoliosis (AIS) is a structural lateral spinal curvature of≥
10° with rotation. Approximately 2–3% of children in most populations are affected with AIS …

[HTML][HTML] Suppl-9, M3: Etiological Theories of Adolescent Idiopathic Scoliosis: Past and Present

M Fadzan, J Bettany-Saltikov - The open orthopaedics journal, 2017 - ncbi.nlm.nih.gov
Adolescent idiopathic scoliosis is one of the most common spinal deformities, yet its cause is
unknown. Various theories look to biomechanical, neuromuscular, genetic, and …

[HTML][HTML] How 'idiopathic'is adolescent idiopathic scoliosis? A systematic review on associated abnormalities

TPC Schlösser, GJMG van der Heijden, AL Versteeg… - PloS one, 2014 - journals.plos.org
Background Despite more than a century of dedicated research, the etiology and
pathogenesis of adolescent idiopathic scoliosis (AIS) remain unclear. By …

Whither the etiopathogenesis (and scoliogeny) of adolescent idiopathic scoliosis

RG Burwell, PH Dangerfield - Stud Health Technol Inform, 2012 - books.google.com
Although considerable progress had been made in the past two decades in understanding
the etiopathogenesis of adolescent idiopathic scoliosis (AIS), it still lacks an agreed theory of …

From genetics to epigenetics to unravel the etiology of adolescent idiopathic scoliosis

G Pérez-Machado, E Berenguer-Pascual… - Bone, 2020 - Elsevier
Scoliosis is defined as the three-dimensional (3D) structural deformity of the spine with a
radiological lateral Cobb angle (a measure of spinal curvature) of≥ 10° that can be caused …