Purpose Cancer has a multitude of phenotypic expressions and identifying these are
important for correct diagnosis and treatment selection. Clinical molecular imaging such as …

Abstract 13 C Magnetic Resonance Spectroscopy (MRS) using hyperpolarized 13 C-labeled
pyruvate as a substrate offers a measure of pyruvate-lactate interconversion and is thereby a …

Abnormalities of tumor metabolism can be exploited for molecular imaging. PET imaging of
18F-FDG is a well-established method using the avid glucose uptake of tumor cells. 13C MR …

With the introduction of combined PET/MR spectroscopic (MRS) imaging, it is now possible
to directly and indirectly image the Warburg effect with hyperpolarized 13C-pyruvate and …

In this paper we demonstrate, for the first time, the feasibility of a new imaging concept-
combined hyperpolarized 13 C-pyruvate magnetic resonance spectroscopic imaging (MRSI) …

Clinical oncology relies increasingly on biomedical imaging, with anatomical imaging,
especially using CT and 1H-MRI, forming the mainstay of patient assessment, from …

In this communication the mismatch between simultaneous 18F-FDG-PET and a 13C-lactate
imaging (hyperPET) in a biopsy verified squamous cell carcinoma in the right tonsil of a …

Precisely measuring tumor-associated alterations in metabolism clinically will enable the
efficient assessment of therapeutic responses. Advances in imaging technologies can …

Abstract 13C-pyruvate hyperpolarized magnetic resonance imaging (HP-MRI) is emerging
as a viable quantitative biomarker for solid tumor response and normal tissue toxicity after …

Abstract Hyperpolarized (HP) MRI using [1-13C] pyruvate is a novel method that can
characterize energy metabolism in the human brain and brain tumors. Here, we present the …