Apelin-36 mediates neuroprotective effects by regulating oxidative stress, autophagy and apoptosis in MPTP-induced Parkinson's disease model mice

J Zhu, W Gao, X Shan, C Wang, H Wang, Z Shao… - Brain research, 2020 - Elsevier
Abstract Parkinson's disease (PD), a common human neurodegenerative disorder, is
characterized by the presence of intraneuronal Lewy bodies composed principally of …

Apelin-13 protects dopaminergic neurons in MPTP-induced Parkinson's disease model mice through inhibiting endoplasmic reticulum stress and promoting …

J Zhu, S Dou, Y Jiang, J Chen, C Wang, B Cheng - Brain Research, 2019 - Elsevier
The dopaminergic neurodegeneration in the substantia nigra pars compacta (SNpc) and
striatum of the midbrain is the important pathological feature of Parkinson's disease (PD). It …

Apelin-36 mitigates MPTP/MPP+-induced neurotoxicity: Involvement of α-synuclein and endoplasmic reticulum stress

J Zhu, S Dou, C Wang, Y Jiang, C Wang, B Cheng - Brain Research, 2019 - Elsevier
Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons
within the substantia nigra compacta (SNpc) which leads to the behavioral dysfunction. In …

Apelin-36 exerts the cytoprotective effect against MPP+-induced cytotoxicity in SH-SY5Y cells through PI3K/Akt/mTOR autophagy pathway

J Zhu, S Dou, Y Jiang, B Bai, J Chen, C Wang… - Life sciences, 2019 - Elsevier
Aims Parkinson's disease (PD) is a common neurodegenerative disease typically
associated with the accumulation of α-synuclein. Autophagy impairment is thought to be …

Protective effect of neuropeptide apelin-13 on 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y dopaminergic cells: involvement of its antioxidant and …

E Pouresmaeili-Babaki, S Esmaeili-Mahani… - Rejuvenation …, 2018 - liebertpub.com
Parkinson's disease (PD) is a severe neurodegenerative disorder characterized by the loss
of brain dopaminergic neurons. Beside pharmacologic and symptomatic treatment of PD the …

Apelin-13 protects PC12 cells against methamphetamine-induced oxidative stress, autophagy and apoptosis

K Foroughi, M Khaksari, M Rahmati, FS Bitaraf… - Neurochemical …, 2019 - Springer
Methamphetamine (METH) is a potent psychomotor stimulant that has a high potential for
abuse in humans. In addition, it is neurotoxic, especially in dopaminergic neurons. Long …

Apelin-13 improves cognitive impairment and repairs hippocampal neuronal damage by activating PGC-1α/PPARγ signaling

B Chen, J Wu, S Hu, Q Liu, H Yang, Y You - Neurochemical Research, 2023 - Springer
Alzheimer's disease (AD) is a complex neurodegenerative disease that is prevalent around
the world. Both Apelin-13 and proliferator-activated receptor-γ (PPARγ)/PPARγ co-activator …

Apelin-13 inhibits apoptosis and excessive autophagy in cerebral ischemia/reperfusion injury

ZQ Shao, SS Dou, JG Zhu, HQ Wang… - Neural regeneration …, 2021 - journals.lww.com
Apelin-13 is a novel endogenous ligand for an angiotensin-like orphan G-protein coupled
receptor, and it may be neuroprotective against cerebral ischemia injury. However, the …

Apelin-13 protects dopaminergic neurons against rotenone—induced neurotoxicity through the AMPK/mTOR/ULK-1 mediated autophagy activation

P Chen, Y Wang, L Chen, N Song, J Xie - International Journal of …, 2020 - mdpi.com
Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons
in the substantia nigra pars compacta. Several brain–gut peptides are able to exert …

Apelin-13/APJ system attenuates early brain injury via suppression of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation and oxidative …

W Xu, T Li, L Gao, J Zheng, J Yan, J Zhang… - Journal of …, 2019 - Springer
Background Neuroinflammation and oxidative stress play important roles in early brain
injury following subarachnoid hemorrhage (SAH). This study is the first to show that …