The majority of cardiovascular randomized controlled trials (RCTs) test interventions in
selected patient populations under explicitly protocol-defined settings. Although these …

Importance Pragmatic trials test interventions using designs that produce results that may be
more applicable to the population in which the intervention will be eventually applied …

Randomized, clinical trials are commonly regarded as the highest level of evidence to
support clinical decisions. Good Clinical Practice guidelines have been constructed to …

Introduction Pragmatic randomized controlled trials (RCTs) mimic usual clinical practice and
they are critical to inform decision-making by patients, clinicians and policy-makers in real …

This is the introductory paper in a series of eight papers. In this series, we integrate the
theoretical design options with the practice of conducting pragmatic trials. For most new …

Randomized clinical trials often serve the purpose of assessing the efficacy and safety of a
compound. By combining real-world evidence and randomization, pragmatic randomized …

Concerns about the external validity of traditional randomized clinical trials (RCTs), together
with the widespread availability of real-world data and advanced data analytic tools, have …

Explanatory and pragmatic trials represent ends of a continuum of attitudes about clinical
trial design. Recent literature argues that pragmatic trials are more informative about clinical …

Traditional randomized controlled trials are the 'gold standard'for evaluating health
interventions and are typically designed to maximize internal validity, often at the cost of …

Objective We established a large database of trials to serve as a resource for future
methodological and ethical analyses. Here, we use meta-data to describe the broad …