Oxidative stress regulation and related metabolic pathways in epithelial–mesenchymal transition of breast cancer stem cells

R Farahzadi, B Valipour, E Fathi, S Pirmoradi… - Stem Cell Research & …, 2023 - Springer
Epithelial–mesenchymal transition (EMT) is a cell remodeling process in which epithelial
cells undergo a reversible phenotype switch via the loss of adhesion capacity and …

[HTML][HTML] Exploring the metabolic vulnerabilities of epithelial–mesenchymal transition in breast cancer

X Sun, M Wang, M Wang, L Yao, X Li… - Frontiers in Cell and …, 2020 - frontiersin.org
Metastasis and drug resistance are the leading causes of death for breast cancer patients.
Epithelial–mesenchymal transition (EMT), a transition from polarized epithelial cells to motile …

Epithelial-to-mesenchymal transition signaling pathways responsible for breast cancer metastasis

B Buyuk, S Jin, K Ye - Cellular and molecular bioengineering, 2022 - Springer
Breast carcinoma is highly metastatic and invasive. Tumor metastasis is a convoluted and
multistep process involving tumor cell disseminating from their primary site and migrating to …

[HTML][HTML] EMT factors and metabolic pathways in cancer

I Georgakopoulos-Soares, DV Chartoumpekis… - Frontiers in …, 2020 - frontiersin.org
The epithelial-mesenchymal transition (EMT) represents a biological program during which
epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is …

Metabolomic and mitochondrial fingerprinting of the epithelial-to-mesenchymal transition (EMT) in non-tumorigenic and tumorigenic human breast cells

E Cuyàs, S Fernández-Arroyo, S Verdura, R Lupu… - Cancers, 2022 - mdpi.com
Simple Summary Epithelial-to-mesenchymal transition (EMT) is a cellular program that
enables epithelial cells to transition toward a mesenchymal phenotype with augmented …

Role of oxidative stress and the microenvironment in breast cancer development and progression

A Jezierska-Drutel, SA Rosenzweig… - Advances in cancer …, 2013 - Elsevier
Breast cancer is a highly complex tissue composed of neoplastic and stromal cells.
Carcinoma-associated fibroblasts (CAFs) are commonly found in the cancer stroma, where …

Epithelial-mesenchymal transition and breast cancer

Y Wu, M Sarkissyan, JV Vadgama - Journal of clinical medicine, 2016 - mdpi.com
Breast cancer is the most common cancer in women and distant site metastasis is the main
cause of death in breast cancer patients. There is increasing evidence supporting the role of …

Epithelial–mesenchymal transition induces similar metabolic alterations in two independent breast cancer cell lines

Y Kondaveeti, IKG Reed, BA White - Cancer letters, 2015 - Elsevier
Epithelial–mesenchymal transition (EMT) induces invasive properties in epithelial tumors
and promotes metastasis. Although EMT-mediated cellular and molecular changes are well …

[HTML][HTML] The flick of a switch: conferring survival advantage to breast cancer stem cells through metabolic plasticity

HR Walsh, BM Cruickshank, JM Brown… - Frontiers in …, 2019 - frontiersin.org
Within heterogeneous tumors, cancer stem cell (CSC) populations exhibit the greatest tumor
initiation potential, promote metastasis, and contribute to therapy resistance. For breast …

Spatial and Temporal Relationship between Epithelial–Mesenchymal Transition (EMT) and Stem Cells in Cancer

P Den Hollander, JJ Maddela, SA Mani - Clinical chemistry, 2024 - academic.oup.com
Background Epithelial–mesenchymal transition (EMT) is often linked with carcinogenesis.
However, EMT is also important for embryo development and only reactivates in cancer …