Advances in pulmonary drug delivery devices for the treatment of chronic obstructive pulmonary disease

M Cazzola, F Cavalli, OS Usmani… - Expert opinion on drug …, 2020 - Taylor & Francis
Introduction Proper device selection is crucial for the clinical results of inhalation therapy.
However, none of the available devices fully conforms to the requirements for delivering …

New inhaler devices-the good, the bad and the ugly

F Lavorini, GA Fontana, OS Usmani - Respiration, 2014 - karger.com
Drug delivery to the lungs is an effective way of targeting inhaled therapeutic aerosols and
treating obstructive airway diseases, such as asthma and chronic obstructive pulmonary …

[HTML][HTML] Optimizing drug delivery in COPD: the role of inhaler devices

P Rogliani, L Calzetta, A Coppola, F Cavalli, J Ora… - Respiratory …, 2017 - Elsevier
Background Inhaled medication is the cornerstone of the pharmacological treatment for
patients with asthma and chronic obstructive pulmonary disease (COPD). Several inhaler …

Inhalation devices: from basic science to practical use, innovative vs generic products

M Pirozynski, TR Sosnowski - Expert opinion on drug delivery, 2016 - Taylor & Francis
Introduction: Inhalation therapy is a convenient method of treating respiratory diseases. The
key factors required for inhalation are the preparation of drug carriers (aerosol particles) …

[HTML][HTML] Will pulmonary drug delivery for systemic application ever fulfill its rich promise?

D Cipolla - Expert opinion on drug delivery, 2016 - Taylor & Francis
While oral delivery of tablets and capsules remains the preferred treatment modality for most
patients, inhaled therapeutics have dominated the landscape for managing many common …

Improving inhaler technique, adherence to therapy and the precision of dosing: major challenges for pulmonary drug delivery

S Newman - Expert Opinion on Drug Delivery, 2014 - Taylor & Francis
Introduction: The inhaled route has many advantages, but requires the patient to use, and to
master the use of, an inhaler device. Poor inhaler technique and non-adherence to therapy …

Inhaled drug delivery: a practical guide to prescribing inhaler devices

P Ernst - Canadian Respiratory Journal, 1998 - Wiley Online Library
Direct delivery of medication to the target organ results in a high ratio of local to systemic
bioavailability and has made aerosol delivery of respiratory medication the route of choice …

Innovations and perspectives of metered dose inhalers in pulmonary drug delivery

M Keller - International Journal of Pharmaceutics, 1999 - Elsevier
The phase-out of chlorofluorocarbons (CFCs) has spurred the development of alternative
pulmonary drug delivery systems to pressurized metered dose inhalers (MDIs), such as dry …

New treatments for chronic obstructive pulmonary disease and viable formulation/device options for inhalation therapy

S Onoue, S Misaka, Y Kawabata… - Expert Opinion on Drug …, 2009 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is an increasingly important cause of
morbidity and mortality, pathological features of which are pulmonary inflammation and …

[HTML][HTML] Importance of inhaler devices in the management of airway disease

JC Virchow, GK Crompton, R Dal Negro, S Pedersen… - Respiratory …, 2008 - Elsevier
The delivery of drugs by inhalation is an integral component of asthma and chronic
obstructive pulmonary disease (COPD) management. However, even with effective inhaled …