Idealhalers versus realhalers: is it possible to bypass deposition in the upper respiratory tract?

JG Weers, YJ Son, M Glusker, A Haynes… - Journal of Aerosol …, 2019 - liebertpub.com
This review discusses how advances in formulation and device design can be utilized to
dramatically improve lung targeting and dose consistency relative to current marketed dry …

[HTML][HTML] Digital inhalers for asthma or chronic obstructive pulmonary disease: a scientific perspective

AHY Chan, RA Pleasants, R Dhand, SL Tilley… - Pulmonary …, 2021 - Springer
Impressive advances in inhalation therapy for patients with asthma and chronic obstructive
pulmonary disease (COPD) have occurred in recent years. However, important gaps in care …

Dry powder inhaler for pulmonary drug delivery: human respiratory system, approved products and therapeutic equivalence guideline

HG Lee, DW Kim, CW Park - Journal of Pharmaceutical Investigation, 2018 - Springer
Pulmonary drug delivery is the promising delivery route to treat not only respiratory diseases
but also systemic diseases and has proven as a potential delivery route for complex drugs …

[HTML][HTML] Inhaler devices–from theory to practice

J Sanchis, C Corrigan, ML Levy, JL Viejo - Respiratory medicine, 2013 - Elsevier
This brief overview of the factors determining lung deposition of aerosols provides
background information required by health care providers when instructing patients to use …

[HTML][HTML] The clinical relevance of dry powder inhaler performance for drug delivery

P Demoly, P Hagedoorn, AH de Boer, HW Frijlink - Respiratory medicine, 2014 - Elsevier
Background Although understanding of the scientific basis of aerosol therapy with dry
powder inhalers (DPIs) has increased, some misconceptions still persist. These include the …

[HTML][HTML] Co-suspension delivery technology in pressurized metered-dose inhalers for multi-drug dosing in the treatment of respiratory diseases

GT Ferguson, AJ Hickey, S Dwivedi - Respiratory medicine, 2018 - Elsevier
Technologies for long-term delivery of aerosol medications in asthma and chronic
obstructive pulmonary disease have improved over the past 2 decades with advancements …

Choosing the right inhaler for your asthma or COPD patient

OS Usmani - Therapeutics and clinical risk management, 2019 - Taylor & Francis
Appropriate selection and correct use of inhalation devices is an integral component in the
management of asthma and chronic obstructive pulmonary disease (COPD). It is well known …

Dry powder inhalers in COPD, lung inflammation and pulmonary infections

P Muralidharan, D Hayes Jr… - Expert opinion on drug …, 2015 - Taylor & Francis
Introduction: The number of pulmonary diseases that are effectively treated by aerosolized
medicine continues to grow. Areas covered: These diseases include chronic obstructive …

Challenges in inhaled product development and opportunities for open innovation

B Forbes, B Asgharian, LA Dailey, D Ferguson… - Advanced drug delivery …, 2011 - Elsevier
Dosimetry, safety and the efficacy of drugs in the lungs are critical factors in the development
of inhaled medicines. This article considers the challenges in each of these areas with …

How can we bring high drug doses to the lung?

S Claus, C Weiler, J Schiewe, W Friess - European Journal of …, 2014 - Elsevier
In the last decades, dry powder inhalation has become a very attractive option for pulmonary
drug delivery to treat lung diseases like cystic fibroses and lung infections. In contrast to the …