Vascular risk factors, particularly in midlife, confer risk for later-life dementia. The association
is reported for both vascular dementia and Alzheimer disease (AD) dementia. The …

Importance Midlife vascular risk burden is associated with late-life dementia. Less is known
about if and how risk exposure in early adulthood influences late-life brain health. Objective …

Background Midlife vascular risk is associated with late-life cognitive impairment, including
Alzheimer's disease dementia. Less is known about the influence of early adulthood …

Background: Early life characteristics influence many aspects of health in later life. Their
association with, and pathways through which they affect brain health, are less well …

Background The two commonest contributors to late‐life cognitive impairment are
Alzheimer's (AD) and cerebrovascular disease; these two conditions almost invariably …

Objective: To investigate the vascular contribution to longitudinal changes in Alzheimer
disease (AD) biomarkers. Methods: The Alzheimer's Disease Neuroimaging Initiative is a …

Background and Objectives The goals of this work were to quantify the independent and
interactive associations of β-amyloid (Aβ) and white matter hyperintensity volume (WMHV), a …

Objective: Our aim was to test the association of vascular risk factor exposure in midlife with
progression of MRI markers of brain aging and measures of cognitive decline. Methods: A …

The Effect of Vascular Neuropathology on Late-life Cognition: Results from the SMART Project
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Throughout the lifespan, common variations in systemic health and illness contribute to
alterations in vasculature structure and function throughout the body, significantly increasing …