Sex differences in behavior and molecular pathology in the 5XFAD model

A Sil, A Erfani, N Lamb, R Copland… - Journal of …, 2022 - content.iospress.com
Background: The prevalence of Alzheimer's disease (AD) is greater in women compared to
men, but the reasons for this remain unknown. This sex difference has been widely …

Age-related changes in social behaviours in the 5xFAD mouse model of Alzheimer's disease

F Kosel, PT Munoz, JR Yang, AA Wong… - Behavioural Brain …, 2019 - Elsevier
In addition to memory impairments, patients with Alzheimer's disease (AD) exhibit a number
of behavioural and psychological symptoms that can affect social interactions over the …

Sex differences between neuronal loss and the early onset of amyloid deposits and behavioral consequences in 5xFAD transgenic mouse as a model for Alzheimer's …

CH Poon, STN Wong, J Roy, Y Wang, HWH Chan… - Cells, 2023 - mdpi.com
A promising direction in the research on Alzheimer's Disease (AD) is the identification of
biomarkers that better inform the disease progression of AD. However, the performance of …

Sex‐biased hippocampal pathology in the 5XFAD mouse model of Alzheimer's disease: a multi‐omic analysis

JL Bundy, C Vied, C Badger… - Journal of Comparative …, 2019 - Wiley Online Library
Alzheimer's disease is a progressive neurodegenerative disorder and the most common
form of dementia. Like many neurological disorders, Alzheimer's disease has a sex‐biased …

Behavioral and EEG changes in male 5xFAD mice

F Schneider, K Baldauf, W Wetzel, KG Reymann - Physiology & behavior, 2014 - Elsevier
Transgenic animal models of Alzheimer's disease (AD) are widely used to investigate
mechanisms of pathophysiology and cognitive dysfunctions. A model with a very early …

Sexual dimorphism in the 3xTg-AD mouse model and its impact on pre-clinical research

JL Dennison, NR Ricciardi, I Lohse… - Journal of …, 2021 - content.iospress.com
Female sex is a leading risk factor for developing Alzheimer's disease (AD). Sexual
dimorphism in AD is gaining attention as clinical data show that women are not only more …

Sex difference in evolution of cognitive decline: studies on mouse model and the Dominantly Inherited Alzheimer Network cohort

RP Kommaddi, A Verma, G Muniz-Terrera… - Translational …, 2023 - nature.com
Women carry a higher burden of Alzheimer's disease (AD) compared to men, which is not
accounted entirely by differences in lifespan. To identify the mechanisms underlying this …

Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer's disease

V Landel, K Baranger, I Virard, B Loriod… - Molecular …, 2014 - Springer
Background The 5XFAD early onset mouse model of Alzheimer's disease (AD) is gaining
momentum. Behavioral, electrophysiological and anatomical studies have identified age …

[HTML][HTML] Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD mice

C Griñán-Ferré, S Sarroca, A Ivanova… - Aging (Albany …, 2016 - ncbi.nlm.nih.gov
Abstract 5XFAD is an early-onset mouse transgenic model of Alzheimer disease (AD). Up to
now there are no studies that focus on the epigenetic changes produced as a result of Aβ-42 …

Characterization of apathy-like behaviors in the 5xFAD mouse model of Alzheimer's disease

R Keszycki, G Rodriguez, JT Dunn, A Locci… - Neurobiology of …, 2023 - Elsevier
Most patients with Alzheimer's disease (AD) develop neuropsychiatric symptoms (NPS)
alongside cognitive decline, and apathy is one of the most common symptoms. Few …