Viruses are believed to contribute to the pathogenesis of autoimmune type 1A diabetes in
humans. This pathogenic process can be modeled in the BBDR rat, which develops …

Kilham rat virus (KRV) infection of BB/Wor diabetes-resistant (DR) RT1u rats induces
autoimmune diabetes without direct cytolytic infection of pancreatic β-cells and is a new …

We used the LEW1. WR1 rat to test the hypothesis that Kilham rat virus-induced innate
immune activation is involved in the mechanism of autoimmune diabetes. Animals were …

Kilham rat virus (KRV) causes autoimmune diabetes in diabetes-resistant BioBreeding (DR-
BB) rats; however, the mechanism by which KRV induces autoimmune diabetes without the …

More than 10 viruses have been reported to be associated with the development of type 1
diabetes‐like symptoms in animals, with the best evidence coming from studies on the D …

The induction of autoimmunity by viruses has been attributed to numerous mechanisms. In
mice, coxsackievirus B4 (CB4) induces insulin-dependent diabetes mellitus (IDDM) …

A parvovirus serologically identified as Kilham rat virus (KRV) reproducibly induces acute
type I diabetes in diabetes-resistant BB/Wor rats. The tissue tropism of KRV was investigated …

Autoimmune diabetes mellitus affects> 50% of diabetes-prone BB (DP BB) rats but< 1% of
diabetes-resistant BB (DR BB) rats. We report an outbreak of spontaneous diabetes among …

Type 1 diabetes results from the progressive destruction of insulin-producing pancreatic
beta cells. Although the etiology of type 1 diabetes is believed to have a major genetic …

In the nonobese diabetic (NOD) mouse, pathogenic and suppressor CD4+ T cells can be
distinguished by the constitutive expression of CD25. In this study, we demonstrate that the …