The role of mitochondrial activity in female fertility and assisted reproductive technologies: overview and current insights

GN Cecchino, E Seli, ELA da Motta… - Reproductive …, 2018 - Elsevier
Mitochondria have been implicated as key factors regulating female reproductive processes.
Notable progress has been made in determining the role of mitochondria with respect to …

The activity and copy number of mitochondrial DNA in ovine oocytes throughout oogenesis in vivo and during oocyte maturation in vitro

M Cotterill, SE Harris… - Molecular human …, 2013 - academic.oup.com
Mitochondria are responsible for the production of ATP, which drives cellular metabolic and
biosynthetic processes. This is the first study to quantify the mtDNA copy number across all …

Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency

GLM Cagnone, TS Tsai, Y Makanji, P Matthews… - Scientific reports, 2016 - nature.com
An increasing number of women fail to achieve pregnancy due to either failed fertilization or
embryo arrest during preimplantation development. This often results from decreased oocyte …

Oxygen concentration alters mitochondrial structure and function in in vitro fertilized preimplantation mouse embryos

M Belli, L Zhang, X Liu, A Donjacour… - Human …, 2019 - academic.oup.com
STUDY QUESTION Does the oxygen concentration in the culture medium [either physiologic
(5%) or atmospheric (20%)] affect mitochondrial ultrastructure and function in …

[HTML][HTML] Mitochondria as a tool for oocyte rejuvenation

E Labarta, MJ de Los Santos, MJ Escribá, A Pellicer… - Fertility and sterility, 2019 - Elsevier
Ovarian aging leads to a decrease in the quantity and quality of oocytes. Aged oocytes have
significantly reduced amounts of mitochondria, the energy factories of cells, leading to lower …

Mitochondria: participation to infertility as source of energy and cause of senescence

M Benkhalifa, YJ Ferreira, H Chahine, N Louanjli… - The international journal …, 2014 - Elsevier
Mitochondria is a powerhouse organelle involved in ATP synthesis, calcium signaling,
reactive oxygen species (ROS) by oxidative stress production, cell cycle arrest via apoptosis …

Alterations in oocyte mitochondrial number and function are related to spindle defects and occur with maternal aging in mice and humans

R Pasquariello, AF Ermisch, E Silva… - Biology of …, 2019 - academic.oup.com
The objective of this work was to determine the role of mitochondria in the loss of oocyte
quality with maternal aging. Our results show that mitochondrial DNA (mtDNA) copy number …

Reproductive aging is associated with changes in oocyte mitochondrial dynamics, function, and mtDNA quantity

E Babayev, T Wang, K Szigeti-Buck, K Lowther… - Maturitas, 2016 - Elsevier
Mitochondria affect numerous aspects of mammalian reproduction. We investigated whether
the decrease in oocyte quality associated with aging is related to altered mitochondria …

[HTML][HTML] Changes in the distribution of mitochondria before and after in vitro maturation of human oocytes and the effect of in vitro maturation on mitochondria …

S Liu, Y Li, X Gao, JH Yan, ZJ Chen - Fertility and sterility, 2010 - Elsevier
OBJECTIVE: To clarify the relationship between oocyte maturation and mitochondria
distribution and assess the effects of in vitro maturation (IVM) on the distribution of …

Change of the Mitochondrial Distribution in Mouse OoplasmDuring In Vitro Maturation

Y Nishi, T Takeshita, K Sato, T Araki - Journal of Nippon Medical …, 2003 - jstage.jst.go.jp
Mitochondria (mt) have been reported to be closely related to the maturation of mammalian
oocytes, but their function in oocyte maturation has not been elucidated. In this study, we …