Purpose To establish the phenotype of reproductive aging in our mouse model. To test the
hypotheses that reproductive aging is associated with a decrease in mitochondrial …

Mitochondrial DNA content varies considerably in oocytes, even when collected from the
same patient. In the present study, real-time quantitative polymerase chain reaction analysis …

The decline of oocyte quality has profound impacts on fertilization, implantation, embryonic
development, and the genetic quality of future generations. One factor that is often ignored …

Germinal vesicle transplantation (GVT) has been proposed as a possible treatment to
correct age-related oocyte aneuploidy caused by dysfunctional ooplasm. How healthy …

Mitochondria are fundamental organelles in eukaryotic cells that provide ATP through
oxidative phosphorylation. During this process, reactive oxygen species (ROS) are …

BACKGROUND Insulin resistance (IR) and hyperinsulinemia compromise fertility in females
and are well-recognized characteristics of anovulatory women with polycystic ovary …

The production of reactive oxygen species (ROS) is a normal process that occurs in the
cellular mitochondrial respiratory chain. However, an increase in ROS levels during in vitro …

Obesity is associated with ovulatory disorders, decreased rates of conception, infertility,
early pregnancy loss and congenital abnormalities. Poor oocyte quality and reduced IVF …

STUDY QUESTION Do mitochondria-targeted therapies reverse ageing-and oxidative stress-
induced spindle defects in oocytes from mice and humans? SUMMARY ANSWER Exposure …

Impaired oocyte quality has been demonstrated in diabetic mice; however, the potential
pathways by which maternal diabetes exerts its effects on the oocyte are poorly understood …