[引用][C] The role of inflammation in the regulation of airway smooth muscle cell function and growth

AL Lazaar, Y Amrani, RA Panettieri Jr - Asthma and Rhinitis, 2000 - Wiley Online Library
This chapter contains section titled: Introduction Airway Smooth Muscle Cell Proliferation
Cytokines Modulate Calcium Homeostasis and Cell Adhesion Molecule Expression in …

Effects of Inflammatory Cytokines on Ca2+ Homeostasis in Airway Smooth Muscle Cells

H Matsumoto - Calcium Signaling In Airway Smooth Muscle Cells, 2014 - Springer
Crosstalk between airway inflammation and airway smooth muscle cells (ASMCs)
contributes to airway hyperresponsiveness, a cardinal feature of asthma. The main putative …

Factors controlling smooth muscle proliferation and airway remodelling

JL Black, PRA Johnson - Current Opinion in Allergy and Clinical …, 2002 - journals.lww.com
It is clear that airway smooth muscle plays an important role in the hyperresponsiveness and
remodelling that occur in the asthmatic airway. This is by virtue of its roles as a contractile …

Point: Counterpoint: Alterations in airway smooth muscle phenotype do/do not cause airway hyperresponsiveness in asthma

SJ Gunst, RA Panettieri Jr - Journal of applied physiology, 2012 - journals.physiology.org
Airway hyperresponsiveness and obstruction are cardinal features of asthma. Compelling
evidence now suggests that the key features of asthma in part are due to intrinsic differences …

Modulation of calcium homeostasis as a mechanism for altering smooth muscle responsiveness in asthma

Y Amrani, RA Panettieri Jr - Current opinion in allergy and clinical …, 2002 - journals.lww.com
Airway hyperresponsiveness remains a defining characteristic of asthma. Traditional views
assert that airway smooth muscle is an important structural effector cell in the bronchi that …

Airway smooth muscle in asthma: linking contraction and mechanotransduction to disease pathogenesis and remodelling

PB Noble, CD Pascoe, B Lan, S Ito… - Pulmonary …, 2014 - Elsevier
Asthma is an obstructive airway disease, with a heterogeneous and multifactorial
pathogenesis. Although generally considered to be a disease principally driven by chronic …

Inflammation signals airway smooth muscle cell proliferation in asthma pathogenesis

MA Khan - Multidisciplinary respiratory medicine, 2013 - Springer
Background Airway inflammation stimulates proliferation of airway smooth muscle cell,
which contributes to the development of hyperplasia and hypertrophy of smooth muscle cell …

Asthma and respiratory physiology: putting lung function into perspective

GF Sferrazza Papa, GM Pellegrino, R Pellegrino - Respirology, 2014 - Wiley Online Library
Bronchial asthma is a chronic disease characterized by airway hyperresponsiveness, airway
inflammation and remodelling. The hypothesis that the illness is inflammatory in nature has …

Airway smooth muscle as an immunomodulatory cell: a new target for pharmacotherapy?

AL Lazaar, RA Panettieri Jr - Current opinion in pharmacology, 2001 - Elsevier
Asthma is a disease characterized, in part, by reversible airflow obstruction,
hyperresponsiveness and inflammation. Traditional concepts concerning airway …

The effect of asthma therapeutics on signalling and transcriptional regulation of airway smooth muscle function

AJ Ammit, JK Burgess, SJ Hirst, JM Hughes… - Pulmonary …, 2009 - Elsevier
SCOPE OF THE REVIEW: Our knowledge of the multifunctional nature of airway smooth
muscle (ASM) has expanded rapidly in the last decade, but the underlying molecular …