Whereas the role of bronchial smooth muscle remains controversial in healthy subjects its
role is well established in asthmatics. Bronchial smooth muscle contraction induces airway …

The biological responses of airway smooth muscle (ASM) are diverse, in part due to ASM
phenotype plasticity. ASM phenotype plasticity refers to the ability of ASM cells to change the …

Background: Asthma is characterized by airway remodeling, altered mucus production and
airway smooth muscle cell (ASMC) contraction causing extensive airway narrowing. In …

" Asthma morbidity and mortality are on the rise. From 1980 to 1987, the prevalence rate of
asthma in the United States increased 29 percent, and death rates for asthma as the …

Chronic persistent asthma is characterized by poorly reversible airflow obstruction and
airways inflammation and remodelling. Histopathological studies of airways removed at post …

Airway smooth muscle thickening is a pathological feature that contributes significantly to
airflow limitation and airway hyperresponsiveness in asthma. Ongoing research efforts …

Asthma, a chronic disease characterized by airway hyperreactivity, is an extraordinarily
common cause of pulmonary impairment. Despite considerable research effort, asthma …

Airway remodeling manifested by hyperplasia of airway smooth muscle cells (ASMCs) and
other structural and functional changes is a pathological condition in asthma not addressed …

Airway smooth muscle (ASM) manifests a hyperresponsive phenotype in airway disorders
such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. Current …

The molecular mechanisms governing the contraction of airway smooth muscle have always
been at the forefront of asthma research. New extracellular molecules affecting the …