The contractile capacity of airway smooth muscle is not fixed but modulated by an
impressive number of extracellular inflammatory mediators. Targeting the transient …

Human airway smooth muscle (ASM) has several properties and functions that contribute to
asthma pathogenesis, and increasing attention is being paid to its synthetic capabilities …

Smooth muscle comprises a key functional component of both the airways and their
supporting vasculature. Dysfunction of smooth muscle contributes to and exacerbates a host …

The contribution of airway smooth muscle (ASM) to asthma is critical but the multiple ways in
which it may contribute to its pathobiology is still an active area of exploration. Contractile …

Airway hyper-responsiveness associated with asthma is mediated by airway smooth muscle
cells (SMCs) and has a complicated etiology involving increases in cell contraction and …

Asthma is characterised by airway hyperresponsiveness, airway inflammation and airway
remodelling. Airway smooth muscle cells are known to be the main effector cells of airway …

It has long been known that airway smooth muscle (ASM) contraction contributes
significantly to the reversible airflow obstruction that defines asthma. It has also been …

Airway smooth muscle plays a pivotal role in modulating bronchomotor tone. Modulation of
contractile and relaxation signaling is critical to alleviate the airway hyperresponsiveness …

The airway smooth muscle cell has a variety of properties, which confer on it the ability to
participate actively in the inflammatory process and the remodeling events, which …

Airway hyperresponsiveness (AHR) and inflammation are key pathophysiological features of
asthma. Enhanced contraction of bronchial smooth muscle (BSM) is one of the causes of the …