Rho-kinase (ROCKs) belongs to the family of serine/threonine kinases and is an important
downstream effector of the small GTP-binding protein RhoA. There are two isoforms of Rho …

Rho kinase (ROCK) is a major downstream effector of the small GTPase RhoA. ROCK
family, consisting of ROCK1 and ROCK2, plays central roles in the organization of actin …

Rho kinases (ROCKs) are the first and the best-characterized effectors of the small G-protein
RhoA. In addition to their effect on actin organization, or through this effect, ROCKs have …

A Rho-associated coiled-coil kinase (ROCK) is identified as a critical downstream effector of
GTPase RhoA which contains two isoforms, ROCK1 (also known as p160ROCK and ROKβ) …

ABSTRACT Introduction: The Rho-kinases (ROCK), ROCK1 and ROCK2, are potent,
widespread biochemical modulators which have been extensively studied. Due to the …

Recent studies using known Rho-associated kinase isoform 1 (ROCK1) inhibitors along with
cellular and molecular biology data have revealed a pivotal role of this enzyme in many …

ROCKs are important regulators of the actin cytoskeleton. Because changes in the actin
cytoskeleton underlie vascular contractility and remodeling, inflammatory cell recruitment …

Rho-associated coiled-coil forming protein kinases (ROCKs), the downstream target
proteins of RhoA, are ubiquitously expressed serine-threonine protein kinases. ROCKs have …

Identified as a major downstream effector of the small GTPase RhoA, Rho-associated coiled-
coil kinase (ROCK) is a versatile regulator of multiple cellular processes. Angiogenesis, the …

Rho-associated, coiled-coil containing kinases (ROCK) were originally identified as effectors
of the RhoA small GTPase and found to belong to the AGC family of serine/threonine …