Objective—Rho/Rho-kinase (ROCK) pathway in vascular smooth muscle cells (VSMCs)
plays an important role in the pathogenesis of cardiovascular diseases, including pulmonary …

Rho kinase (ROCK) proteins are Rho-GTPase activated serine/threonine kinases that
function as modulators of actin-myosin cytoskeletal dynamics via regulation of Lin11, Isl-1 & …

Rho‐associated coiled‐coil kinases (ROCKs), initially identified as effectors for Rho
GTPases, play a role in cardiac cell physiology and are also expressed in the developing …

The small GTPase Rho and its downstream effector, Rho-kinase (ROCK), regulate various
cellular functions, including organization of the actin cytoskeleton, cell adhesion and …

Abstract The small Rho GTPase family of proteins, encompassing the three major G-protein
classes Rho, Rac and cell division control protein 42, are key mitogenic signaling molecules …

Objective The purpose of the present study was to determine whether increased activation of
the RhoA/Rho-kinase (ROCK) pathway occurs in diabetic cardiomyopathy and whether …

Background and purpose: Rho‐kinase (ROCK) has been implicated in the pathophysiology
of altered vasoregulation leading to hypertension. Here we describe the pharmacological …

Abnormal vascular smooth muscle cell (VSMC) contraction plays an important role in
vascular diseases. The RhoA/ROCK signaling pathway is now well recognized to mediate …

Rho-kinase (ROCK) is a serine/threonine kinase and one of the major downstream effectors
of the small GTPase Rho. The Rho-ROCK pathway is involved in many aspects of neuronal …

Abstract The small GTPase Rho and its effector Rho kinase (ROCK) are involved in the
pathogenesis of diabetic kidney disease. Rho kinase has two isoforms: ROCK1 and ROCK2 …