Targeting vascular (endothelial) dysfunction

A Daiber, S Steven, A Weber… - British journal of …, 2017 - Wiley Online Library
Cardiovascular diseases are major contributors to global deaths and disability‐adjusted life
years, with hypertension a significant risk factor for all causes of death. The endothelium that …

Oxidative stress and endothelial dysfunction

C Urso, G Caimi - Minerva medica, 2011 - europepmc.org
Endothelial dysfunction and oxidative stress are the main pathophysiological mechanisms of
several diseases such as hypertension, atherosclerosis, dyslipidemia, diabetes mellitus …

[HTML][HTML] Targeting oxidative stress in disease: Promise and limitations of antioxidant therapy

HJ Forman, H Zhang - Nature Reviews Drug Discovery, 2021 - nature.com
Oxidative stress is a component of many diseases, including atherosclerosis, chronic
obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small …

Hyperglycemia-induced oxidative stress and its role in diabetes mellitus related cardiovascular diseases

T Vanessa Fiorentino, A Prioletta… - Current …, 2013 - ingentaconnect.com
Diabetes mellitus is associated to an increased risk of cardiovascular diseases.
Hyperglycemia is an important factor in cardiovascular damage, working through different …

Redox signaling in cardiovascular health and disease

NR Madamanchi, MS Runge - Free Radical Biology and Medicine, 2013 - Elsevier
Spatiotemporal regulation of the activity of a vast array of intracellular proteins and signaling
pathways by reactive oxygen species (ROS) governs normal cardiovascular function …

[HTML][HTML] The antioxidant therapy: new insights in the treatment of hypertension

D Sorriento, N De Luca, B Trimarco… - Frontiers in …, 2018 - frontiersin.org
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play a key role in the
regulation of the physiological and pathological signaling within the vasculature. In …

Oxidative stress–chronic kidney disease–cardiovascular disease: A vicious circle

V Ravarotto, F Simioni, E Pagnin, PA Davis, LA Calò - Life sciences, 2018 - Elsevier
Chronic kidney disease patient's progression to end-stage renal disease as well as their
high mortality are linked to cardiovascular disease. However, the high incidence rate of …

Evolving concepts of oxidative stress and reactive oxygen species in cardiovascular disease

K Chen, JF Keaney - Current atherosclerosis reports, 2012 - Springer
Cardiovascular disease (CVD) continues to be a substantial health-care burden, despite
recent treatment advances. Oxidative stress has long been regarded as a key …

[HTML][HTML] Role of oxidative stress in the pathogenesis of atherothrombotic diseases

G Petrucci, A Rizzi, D Hatem, G Tosti, B Rocca… - Antioxidants, 2022 - mdpi.com
Oxidative stress is generated by the imbalance between reactive oxygen species (ROS)
formation and antioxidant scavenger system's activity. Increased ROS, such as superoxide …

Management of oxidative stress and inflammation in cardiovascular diseases: mechanisms and challenges

T Donia, A Khamis - Environmental Science and Pollution Research, 2021 - Springer
Cardiovascular diseases (CVDs) have diverse physiopathological mechanisms with
interconnected oxidative stress and inflammation as one of the common etiologies which …