Purpose Pseudomonas aeruginosa is a commonly isolated nosocomial pathogen for which
treatment options are often limited for multidrug-resistant isolates. In addition to newer …

Background: Pseudomonas aeruginosa, one of the leading causes of nosocomial gram-
negative bloodstream infections, is particularly difficult to treat because of its multiple …

Study Objective. To compare conventional intermittent dosing regimens of piperacillin‐
tazobactam with prolonged and continuous infusions to determine the optimal dosing …

This objective of this study was to compare clinical outcomes in hospitalized patients with
Pseudomonas aeruginosa pneumonia (PNA) or bloodstream infection (BSI) receiving beta …

Beta-lactam antibiotics are often the backbone of treatment for Gram-negative infections in
the critically ill. Beta-lactams exhibit time-dependent killing, and their efficacy depends on …

The study of pharmacodynamics has greatly enhanced our understanding of antimicrobials
and has enabled us to optimize dosing regimens. Applying this knowledge to the clinical …

Given the inconsistent clinical findings, our goal was to characterize the pharmacodynamics
(PDs) of prolonged-infusion piperacillin-tazobactam (TZP) in an in vitro pharmacodynamic …

Objectives To compare the clinical and microbiological outcomes of patients treated with
beta-lactam monotherapy or combination therapy for Pseudomonas aeruginosa infections …

Objectives: In order to explore the pharmacodynamic need for continuous versus intermittent
(three times a day) administration of ceftazidime in critically ill patients, a pharmacokinetic …

Abstract Study Objectives The most commonly prescribed antibiotics for patients with
hospital‐acquired bacterial pneumonia (HABP) and ventilator‐associated bacterial …