Background. Piperacillin-tazobactam is frequently used to treat Pseudomonas aeruginosa
infections in critically ill patients. In an effort to improve clinical outcomes, an extended …

The optimal dosage and administration of antibiotics are not only important measures to
combat antimicrobial resistance, but they are also integral to antimicrobial stewardship. In …

Pseudomonas aeruginosa is a pathogen frequently encountered in healthcare-associated
infections and immunocompromised patients. In bacteremia, this pathogen is associated …

Intravenous β‐lactam antibiotics remain a cornerstone in the management of bacterial
infections due to their broad spectrum of activity and excellent tolerability. β‐lactams are well …

Multidrug-resistant (MDR)/extensively drug-resistant (XDR) Pseudomonas aeruginosa is
emerging as a major threat related to adverse patient outcomes. The goal of this review is to …

Background Administering β-lactam antibiotics via prolonged infusions for critically ill
patients is mainly based on preclinical evidence. Preclinical data on this topic have not been …

Clinicians have long debated whether prolonged IV infusion of antimicrobials, including ß-
lactams, is a more effective administration strategy than intermittent (“standard”) infusion. 1 …

Multidrug-resistant (MDR) and extensively drug-resistant (XDR) Pseudomonas aeruginosa
isolates are frequent causes of serious nosocomial infections that may compromise the …

This study was conducted to identify optimal dosage regimens and estimate
pharmacokinetic/pharmacodynamic (PK/PD) characteristics of short-infusion (SI) versus …

Introduction In order to compare the clinical efficacy and safety of prolonged versus
intermittent antipseudomonal beta-lactam antibiotic infusion for the treatment of severe acute …