The transient receptor potential cation channel subfamily M 8 (TRPM8) agonist L-menthol
has been used traditionally for its topical counterirritant properties. Although the use of …

Background Activation of TRPM 8 and TRPA 1 receptors generates cold and cold pain
sensations, respectively, and is presumably important in clinical pain manifestations, such …

Menthol is used in analgesic balms and also in foods and oral hygiene products for its fresh
cooling sensation. Menthol enhances cooling by interacting with the cold-sensitive …

Menthol has historically been used topically to alleviate various pain conditions. At low
concentrations, this non-selective TRPM8 agonist elicits a cooling sensation, however …

What is known and objective Menthol has been used as a non‐opioid pain reliever since
ancient times. A modern understanding of its molecular mechanism of action could form the …

Menthol is an important flavoring additive that triggers a cooling sensation. Under
physiological condition, low to moderate concentrations of menthol activate transient …

Menthol, the cooling natural product of peppermint, is widely used in medicinal preparations
for the relief of acute and inflammatory pain in sports injuries, arthritis, and other painful …

Background Previous study showed that extracts from Croton macrostachyus
(Euphorbiaceae) exhibit analgesic effects in acute pain models. The present study evaluates …

menthol, a major form of menthol, is one of the most commonly used chemicals. Many
studies have demonstrated that (−)-menthol produces analgesic action through peripheral …

Background Cold allodynia and cold hyperalgesia are both elusive features of neuropathic
pain, particularly in patients with various polyneuropathies. Numerous studies have …