Baseline insomnia as a predictor of antidepressant efficacy to repeated intravenous ketamine for unipolar and bipolar depression: a preliminary study

W Liu, Y Zhou, C Wang, W Zheng, Y Zhan, X Lan… - Journal of Affective …, 2020 - Elsevier
Objective Ketamine has been demonstrated to have robust and rapid antidepressant effects,
and few studies have focused on the relationship between insomnia and the efficacy of …

Long-term outcomes of repeated ketamine infusions in patients with unipolar and bipolar depression: A naturalistic follow-up study

W Li, Y Zhou, W Liu, C Wang, X Lan, Z Zhang… - Journal of Affective …, 2022 - Elsevier
Objective Ketamine was proven to have short-term antidepressant effects. There is a paucity
of studies focused on the long-term outcomes of repeated infusions of ketamine. This study …

Meta-analysis of short-and mid-term efficacy of ketamine in unipolar and bipolar depression

B Romeo, W Choucha, P Fossati, JY Rotge - Psychiatry research, 2015 - Elsevier
Among treatments currently assessed in major depression, ketamine, has been proposed of
great interest, especially because of its very rapid action. However, the time-course of the …

Replication of ketamine's antidepressant efficacy in bipolar depression: a randomized controlled add-on trial

CA Zarate Jr, NE Brutsche, L Ibrahim… - Biological …, 2012 - Elsevier
BACKGROUND: Currently, no pharmacological treatments for bipolar depression exist that
exert rapid (within hours) antidepressant or antisuicidal effects. We previously reported that …

Rapid and longer-term antidepressant effects of repeated-dose intravenous ketamine for patients with unipolar and bipolar depression

W Zheng, YL Zhou, WJ Liu, CY Wang, YN Zhan… - Journal of psychiatric …, 2018 - Elsevier
Objective Single-dose intravenous (IV) injection of ketamine has shown rapid but transient
antidepressant effects. The strategy of repeated-dose ketamine infusions to maintain …

Patient-reported outcomes on sleep quality and circadian rhythm during treatment with intravenous ketamine for treatment-resistant depression

R Yan, T Marshall, A Khullar, T Nagle… - Therapeutic …, 2024 - journals.sagepub.com
Background: Intravenous (IV) ketamine is a rapid acting antidepressant used primarily for
treatment-resistant depression (TRD). It has been suggested that IV ketamine's rapid …

[HTML][HTML] Efficacy of single and repeated administration of ketamine in unipolar and bipolar depression: a meta-analysis of randomized clinical trials

J Kryst, P Kawalec, AM Mitoraj, A Pilc, W Lasoń… - Pharmacological …, 2020 - Springer
Background Due to unmet clinical needs for efficient drugs with a rapid onset of
antidepressant effects, we aimed to evaluate the efficacy of single-dose ketamine in different …

Sleep improvement is associated with the antidepressant efficacy of repeated-dose ketamine and serum BDNF levels: a post-hoc analysis

M Wang, B Zhang, Y Zhou, C Wang, W Zheng… - Pharmacological …, 2021 - Springer
Rationale Recently, the effects of ketamine on the circadian rhythm have suggested that
ketamine's rapid antidepressant effects are associated with and without sleep disturbance …

[HTML][HTML] Effect of ketamine on sleep in treatment-resistant depression: a systematic review

A Kwaśny, A Włodarczyk, D Ogonowski, WJ Cubała - Pharmaceuticals, 2023 - mdpi.com
Background: Depression is a debilitating disease with a high socioeconomic burden.
Regular antidepressants usually require several weeks to ameliorate symptoms; however …

The effects of ketamine on typical and atypical depressive symptoms

LT Park, DA Luckenbaugh… - Acta Psychiatrica …, 2020 - Wiley Online Library
Objective Ketamine's effects on different dimensions of depressive symptomatology,
including typical/melancholic and atypical depression, remain largely unknown. This study …