Objective Ketamine has been demonstrated to have robust and rapid antidepressant effects,
and few studies have focused on the relationship between insomnia and the efficacy of …

Objective Ketamine was proven to have short-term antidepressant effects. There is a paucity
of studies focused on the long-term outcomes of repeated infusions of ketamine. This study …

Among treatments currently assessed in major depression, ketamine, has been proposed of
great interest, especially because of its very rapid action. However, the time-course of the …

BACKGROUND: Currently, no pharmacological treatments for bipolar depression exist that
exert rapid (within hours) antidepressant or antisuicidal effects. We previously reported that …

Objective Single-dose intravenous (IV) injection of ketamine has shown rapid but transient
antidepressant effects. The strategy of repeated-dose ketamine infusions to maintain …

Background: Intravenous (IV) ketamine is a rapid acting antidepressant used primarily for
treatment-resistant depression (TRD). It has been suggested that IV ketamine's rapid …

Background Due to unmet clinical needs for efficient drugs with a rapid onset of
antidepressant effects, we aimed to evaluate the efficacy of single-dose ketamine in different …

Rationale Recently, the effects of ketamine on the circadian rhythm have suggested that
ketamine's rapid antidepressant effects are associated with and without sleep disturbance …

Background: Depression is a debilitating disease with a high socioeconomic burden.
Regular antidepressants usually require several weeks to ameliorate symptoms; however …

Objective Ketamine's effects on different dimensions of depressive symptomatology,
including typical/melancholic and atypical depression, remain largely unknown. This study …