DNA replication and RNA transcription compete for the same substrate during S phase.
Cells have evolved several mechanisms to minimize such conflicts. Here, we identify the …

Transcription hinders replication fork progression and stability. The ATR checkpoint and
specialized DNA helicases assist DNA synthesis across transcription units to protect …

The yeast RNA/DNA helicase Sen1, Senataxin in human, preserves the integrity of
replication forks encountering transcription by removing RNA-DNA hybrids. Here we show …

Cellular homeostasis requires the coordination of several machineries concurrently
engaged in the DNA. Wide-spread transcription can interfere with other processes, and …

Replication forks terminate at TERs and telomeres. Forks that converge or encounter
transcription generate topological stress. Combining genetics, genomics, and transmission …

Eukaryotic cells regulate the progression and integrity of DNA replication forks to maintain
genomic stability and couple DNA synthesis to other processes. The budding yeast proteins …

The components of the replisome that preserve genomic stability by controlling the
progression of eukaryotic DNA replication forks are poorly understood. Here, we show that …

Degradation and collapse of stalled replication forks are main sources of genomic instability,
yet the molecular mechanisms for protecting forks from degradation/collapse are not well …

The replisome, the molecular machine dedicated to copying DNA, encounters a variety of
obstacles during S phase. Without a proper response to this replication stress, the genome …

Stabilisation of stalled replication forks prevents excessive fork reversal and their
pathological degradation, which can undermine genome integrity. Here we investigate a …