The coordination of DNA unwinding and synthesis at replication forks promotes efficient and
faithful replication of chromosomal DNA. Disruption of the balance between helicase and …

Sen1 of S. cerevisiae is a known component of the NRD complex implicated in transcription
termination of nonpolyadenylated as well as some polyadenylated RNA polymerase II …

Stabilization and processing of stalled replication forks is critical for cell survival and
genomic integrity. We characterize a novel DNA repair heterodimer of Nse5 and Nse6 …

Uncoordinated clashes between replication forks and transcription cause replication stress
and genome instability, which are hallmarks of cancer and neurodegeneration. Here, we …

Genome duplication is carried out by pairs of replication forks that assemble at origins of
replication and then move in opposite directions. DNA replication ends when converging …

The remodeling of stalled replication forks to form four-way DNA junctions is an important
component of the replication stress response. Nascent DNA at the regressed arms of these …

The S phase checkpoint pathway preserves genome stability by protecting defective DNA
replication forks, but the underlying mechanisms are still understood poorly. Previous work …

Abstract Srs2 is a 3′–5′ DNA helicase that regulates many aspects of DNA metabolism in
Saccharomyces cerevisiae. It is best known for its ability to counteract homologous …

In higher eukaryotes, the dynamics of replisome components during fork collapse and restart
are poorly understood. Here we have reconstituted replication fork collapse and restart by …

SMARCAL1 (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin,
subfamily A-like1) maintains genome integrity during DNA replication. Here we investigated …