Cross-talk between cancer stem cells and immune cells: potential therapeutic targets in the tumor immune microenvironment

B Wu, X Shi, M Jiang, H Liu - Molecular Cancer, 2023 - Springer
Ongoing research has revealed that the existence of cancer stem cells (CSCs) is one of the
biggest obstacles in the current cancer therapy. CSCs make an influential function in tumor …

[HTML][HTML] Linking tumor microenvironment to plasticity of cancer stem cells: mechanisms and application in cancer therapy

X Zheng, C Yu, M Xu - Frontiers in Oncology, 2021 - frontiersin.org
Cancer stem cells (CSCs) are a minority subset of cancer cells that can drive tumor initiation,
promote tumor progression, and induce drug resistance. CSCs are difficult to eliminate by …

Bidirectional crosstalk between cancer stem cells and immune cell subsets

L Müller, A Tunger, I Plesca, R Wehner… - Frontiers in …, 2020 - frontiersin.org
Cancer stem cells (CSCs), also known as tumor-initiating cells, are characterized by an
increased capacity for self-renewal, multipotency, and tumor initiation. While CSCs …

Exploring the dynamic interplay between cancer stem cells and the tumor microenvironment: implications for novel therapeutic strategies

YR Li, Y Fang, Z Lyu, Y Zhu, L Yang - Journal of Translational Medicine, 2023 - Springer
Cancer stem cells (CSCs) have emerged as key contributors to tumor initiation, growth, and
metastasis. In addition, CSCs play a significant role in inducing immune evasion, thereby …

Interactions between cancer stem cells, immune system and some environmental components: friends or foes?

F Vahidian, PHG Duijf, E Safarzadeh, A Derakhshani… - Immunology letters, 2019 - Elsevier
Cancer stem cells (CSCs) are a subgroup of tumor cells that are characterized by their tumor
initiating capacity, low proliferation rate, self-renewal capacity, pluripotency and …

[HTML][HTML] Cancer stem cells: emerging key players in immune evasion of cancers

MML Lei, TKW Lee - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Cancer stem cells (CSCs) are subpopulations of undifferentiated cancer cells within the
tumor bulk that are responsible for tumor initiation, recurrence and therapeutic resistance …

The role of cancer stem cells in the modulation of anti-tumor immune responses

C Maccalli, KI Rasul, M Elawad, S Ferrone - Seminars in cancer biology, 2018 - Elsevier
Tumor lesions comprise multiple subpopulations of cells including those endowed with
“stemness” properties. The latter cells are responsible of tumor initiation, metastasis …

Immune evader cancer stem cells direct the perspective approaches to cancer immunotherapy

H Dianat-Moghadam, A Mahari, R Salahlou… - Stem Cell Research & …, 2022 - Springer
Exploration of tumor immunity leads to the development of immune checkpoint inhibitors and
cell-based immunotherapies which improve the clinical outcomes in several tumor types …

[PDF][PDF] Cancer stemness meets immunity: from mechanism to therapy

P Chen, WH Hsu, J Han, Y Xia, RA DePinho - Cell reports, 2021 - cell.com
Cancer stem cells (CSCs) are self-renewing cells that facilitate tumor initiation, promote
metastasis, and enhance cancer therapy resistance. Transcriptomic analyses across many …

Cancer stem cells: regulation programs, immunological properties and immunotherapy

D Zhang, DG Tang, K Rycaj - Seminars in cancer biology, 2018 - Elsevier
It is becoming increasingly clear that virtually all types of human cancers harbor a small
population of stem-like cancer cells (ie, cancer stem cells, CSCs). These CSCs preexist in …