The chemokine receptor CXCR4 and its cognate ligand CXCL12 recently have been
proposed to regulate the directional trafficking and invasion of breast cancer cells to sites of …

Breast tumor cells express the chemokine receptor CXCR3, which binds the ligands CXCL9,
CXCL10, and CXCL11. CXCR3 and other chemokine receptors may mediate tumor …

CXCR4 and its ligand CXCL12 can promote the proliferation, survival, and invasion of
cancer cells. They have been shown to play an important role in regulating metastasis of …

Expression of the chemokine receptor CXCR4 has been linked with increased metastasis
and decreased clinical prognosis in breast cancer. The current paradigm dictates that …

Breast cancer is one of the leading causes of cancer related deaths worldwide. Breast
cancer-related mortality is associated with the development of metastatic potential of primary …

Chemokine CXCL12 and receptor CXCR4 control multiple steps in primary tumor growth
and metastasis in breast cancer and more than 20 other human malignancies. Mechanisms …

Tumor cells aberrantly express chemokines and/or chemokine receptors, and some may
promote tumor growth and metastasis. We examined the expression and function of …

Recent evidence attributed important influence of chemokines and their receptors on
motility, homing, and proliferation of cancer cells at specific metastatic sites. Here we report …

Introduction CXCL12-CXCR4 signaling has been shown to play a role in breast cancer
progression by enhancing tumor growth, angiogenesis, triggering cancer cell invasion in …

Chemokines comprise a superfamily of at least 46 cytokines that were initially described
based on their ability to bind to 18 to 22 G protein-coupled receptors to induce the directed …