Efforts to decipher chronic lung disease and to reconstitute functional lung tissue through
regenerative medicine have been hampered by an incomplete understanding of cell-cell …

Diseases such as idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, and
bronchopulmonary dysplasia injure the gas-exchanging alveoli of the human lung. Animal …

Although single-cell RNA sequencing studies have begun to provide compendia of cell
expression profiles,,,,,,,–, it has been difficult to systematically identify and localize all …

Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the
human lung, but their spatial context is less well defined. To (re) define tissue architecture of …

Pulmonary fibrosis develops as a consequence of failed regeneration after injury. Analyzing
mechanisms of regeneration and fibrogenesis directly in human tissue has been hampered …

Tissue-resident alveolar and interstitial macrophages and recruited macrophages are critical
players in innate immunity and maintenance of lung homeostasis. Until recently, assessing …

The lung is the primary respiratory organ in human, in which the proximal airway and the
distal alveoli are responsible for air conduction and gas exchange, respectively. However …

The respiratory system, including the peripheral lungs, large airways and trachea, is one of
the most recently evolved adaptations to terrestrial life. To support the exchange of …

The lung contains numerous specialized cell types with distinct roles in tissue function and
integrity. To clarify the origins and mechanisms generating cell heterogeneity, we created a …

INTRODUCTION The alveolar region of the lung develops in a period that spans the late
embryonic and early postnatal stages of life. An intricate series of events—including cellular …