The human gut microbiome is a complex ecosystem that can mediate the interaction of the
human host with their environment. The interaction between gut microbes and commonly …

Highlights•Association studies report drug-mediated changes in microbiome signatures.•
Interactions with the microbiome can be part of a drug's mode of action or side effects.• …

Introduction: Gut microbiota plays critical roles in drug metabolism. The variation of gut
microbiota contributes to the interindividual differences toward drug therapy including drug …

The fate and activity of drugs are frequently dictated not only by the host per se but also by
the microorganisms present in the gastrointestinal tract. The gut microbiome is known to …

Systems biology provides an opportunity to discover the role that gut microbiota play in
almost all aspects of human health. Existing evidence supports the hypothesis that gut …

The intestinal microbiome encodes vast metabolic potential, and multidisciplinary
approaches are enabling a mechanistic understanding of how bacterial enzymes impact the …

Gut microbiota is the most diverse and complex biological ecosystem, which is estimated to
consist of greater than 5 million distinct genes and 100 trillion cells which are in constant …

The significance of the gut microbiota as a determinant of drug pharmacokinetics and
accordingly therapeutic response is of increasing importance with the advent of modern …

Evidence is growing that the gut microbiota modulates the host response to
chemotherapeutic drugs, with three main clinical outcomes: facilitation of drug efficacy; …

The human gut microbiota has now been associated with drug responses and efficacy, while
chemical compounds present in these drugs can also impact the gut bacteria. However …