Liver fibrosis is a dynamic condition caused by wound-healing in which scar tissue replaces
the liver parenchyma following repetitive injuries. It is hypothesized that α-mangostin (AM) …

Liver fibrosis is a dynamic condition caused by wound‑healing in which scar tissue replaces
the liver parenchyma following repetitive injuries. It is hypothesized that α‑mangostin (AM) …

Liver fibrosis is an excessive accumulation of scar tissue resulting from inflammation and
cell death. Thioacetamide (TAA) is a well-known hepatotoxin that induces liver fibrosis. A …

Protective effect of alpha-mangostin against type-I collagen formation in thioacetamide-induced
cirrhotic rat. - Abstract - Europe PMC Sign in | Create an account https://orcid.org Europe PMC …

Objective: To determine the effects of alpha-mangostin on thioacetamide (TAA)-induced liver
cirrhosis in rats. Material and Method: Male Wistar rats were divided into 3 groups and …

The increased proliferation and activation of hepatic stellate cells (HSCs) are associated
with liver fibrosis development. To date, there are no FDA-approved drugs for the treatment …

Objective: Alcohol accumulation in the liver can cause pathological disorders such as liver
fibrosis that can develop into hepatocellular carcinoma, one of the main causes of mortality …

ABSTRACT Objective: Alpha-mangostin (α-MG) has been shown to possess antifibrotic
effects. However, the specific mechanism of action of this compound remains poorly …

Liver fibrosis is characterized by excessive accumulation of extracellular matrix in chronic
liver injury. Alcohol‐induced fibrosis may develop into cirrhosis, one of the major causes of …

The activation of hepatic stellate cells (HSCs) plays a critical role in liver fibrosis. In the
current study, γ-mangostin (γ-man), one of the major xanthones from mangosteen (Garcinia …