Purpose Critically ill patients with preserved or increased renal function have been shown to
be at risk of underexposure to meropenem. Although many meropenem population …

Meropenem dosing in critically ill patients with septic shock and continuous renal
replacement therapy (CRRT) is complex, with the recommended maintenance doses being …

Abstract Background and Objectives Meropenem is frequently used for the treatment of
severe bacterial infections in critically ill patients. Because critically ill patients are more …

Effective antibiotic dosing is vital for therapeutic success in critically ill patients. This work
aimed to develop an algorithm to identify appropriate meropenem dosing in critically ill …

Background Meropenem is a carbapenem antibiotic commonly used in critically ill patients
to treat severe infections. The available pharmacokinetic (PK) data has been mostly …

Purpose This study aimed to investigate the pharmacokinetics and target attainment of
meropenem and compare the effect of meropenem dosing regimens in critically ill patients …

Aims To describe the population pharmacokinetics (PK) and probability of target attainment
(PTA) of continuous infusion (CI) of meropenem in septic patients receiving renal …

Several pathophysiological changes can alter meropenem pharmacokinetics in critically ill
patients, thereby increasing the risk of subtherapeutic concentrations and affecting …

The optimal dosing regimen for meropenem in critically ill patients undergoing continuous
renal replacement therapy (CRRT) remains undefined due to small studied sample sizes …

Background Optimal antibiotic exposure is a vital but challenging prerequisite for achieving
clinical success in ICU patients. Objectives To develop and externally validate a population …